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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3762
Target Type SINGLE PROTEIN
Preferred Name Voltage-gated L-type calcium channel alpha-1C subunit
Synonyms Cach2 | Cacn2 | Cacna1c | Cacnl1a1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Cchl1a1 | RBC | Rat brain class C | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent L-type calcium channel subunit alpha-1C SINGLE PROTEIN P22002

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095177 Voltage-gated L-type calcium channel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030018 (Z disc)
GO:0030315 (T-tubule)
GO:0030425 (dendrite)
GO:0042383 (sarcolemma)
GO:0042734 (presynaptic membrane)
GO:0043025 (neuronal cell body)
GO:0043234 (protein complex)
GO:1990454 (L-type voltage-gated calcium channel complex)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0008331 (high voltage-gated calcium channel activity)
GO:0019904 (protein domain specific binding)
GO:0031369 (translation initiation factor binding)
GO:0044325 (ion channel binding)
GO:0046872 (metal ion binding)
GO:0051393 (alpha-actinin binding)
GO:0051721 (protein phosphatase 2A binding)
GO:0086007 (voltage-gated calcium channel activity involved in cardiac muscle cell action potential)
GO:0086056 (voltage-gated calcium channel activity involved in AV node cell action potential)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0034765 (regulation of ion transmembrane transport)
GO:0055085 (transmembrane transport)
GO:0061337 (cardiac conduction)
GO:0061577 (calcium ion transmembrane transport via high voltage-gated calcium channel)
GO:0070509 (calcium ion import)
GO:0070588 (calcium ion transmembrane transport)
GO:0086002 (cardiac muscle cell action potential involved in contraction)
GO:0086010 (membrane depolarization during action potential)
GO:0086012 (membrane depolarization during cardiac muscle cell action potential)
GO:0086045 (membrane depolarization during AV node cell action potential)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:0098911 (regulation of ventricular cardiac muscle cell action potential)
GO:0098912 (membrane depolarization during atrial cardiac muscle cell action potential)

Target Cross References - Protein

canSAR P22002
IntAct P22002
Guide to Pharmacology 529
Reactome R-RNO-400042 (Adrenaline,noradrenaline inhibits insulin secretion.)
UniProt P22002 P27733 P27734 Q62816 Q63271 Q64178

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005446 (VDCC_L_a1su.)
IPR005451 (VDCC_L_a1csu.)
IPR005821 (Ion_trans_dom.)
IPR014873 (VDCC_a1su_IQ.)
IPR027359 (Channel_four-helix_dom.)
IPR031649 (GPHH_dom.)
IPR031688 (CAC1F_C.)
Pfam PF00520 (Ion_trans)
PF08763 (Ca_chan_IQ)
PF16885 (CAC1F_C)
PF16905 (GPHH)

Target Cross References - Structure

PDBe 1VYT
CREDO 1VYT
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