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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3753
Target Type SINGLE PROTEIN
Preferred Name Glutamate receptor ionotropic, AMPA 1
Synonyms AMPA-selective glutamate receptor 1 | GluA1 | GluR-1 | GluR-A | GluR-K1 | Glur1 | Glutamate receptor 1 | Glutamate receptor ionotropic, AMPA 1 | Gria1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > ampa receptor

Target Components

Component Description Relationship Accession
Glutamate receptor 1 SINGLE PROTEIN P19490

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883283 Glutamate receptor AMPA 1/2 PROTEIN COMPLEX
CHEMBL2096669 Glutamate receptors; NMDA/AMPA PROTEIN COMPLEX GROUP
CHEMBL2093871 Glutamate receptor ionotropic, AMPA PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0008328 (ionotropic glutamate receptor complex)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0031594 (neuromuscular junction)
GO:0031901 (early endosome membrane)
GO:0032279 (asymmetric synapse)
GO:0032281 (AMPA glutamate receptor complex)
GO:0032991 (macromolecular complex)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0044309 (neuron spine)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0055038 (recycling endosome membrane)
GO:0060076 (excitatory synapse)
GO:0097060 (synaptic membrane)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0001965 (G-protein alpha-subunit binding)
GO:0004970 (ionotropic glutamate receptor activity)
GO:0004971 (AMPA glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0008179 (adenylate cyclase binding)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0030165 (PDZ domain binding)
GO:0031267 (small GTPase binding)
GO:0031489 (myosin V binding)
GO:0031681 (G-protein beta-subunit binding)
GO:0031698 (beta-2 adrenergic receptor binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0051018 (protein kinase A binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001919 (regulation of receptor recycling)
GO:0006811 (ion transport)
GO:0007165 (signal transduction)
GO:0007616 (long-term memory)
GO:0009636 (response to toxic substance)
GO:0010226 (response to lithium ion)
GO:0014070 (response to organic cyclic compound)
GO:0019228 (neuronal action potential)
GO:0021510 (spinal cord development)
GO:0031623 (receptor internalization)
GO:0032355 (response to estradiol)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0043434 (response to peptide hormone)
GO:0045838 (positive regulation of membrane potential)
GO:0046685 (response to arsenic-containing substance)
GO:0048167 (regulation of synaptic plasticity)
GO:0050804 (modulation of synaptic transmission)
GO:0050806 (positive regulation of synaptic transmission)
GO:0051602 (response to electrical stimulus)
GO:0060079 (excitatory postsynaptic potential)
GO:0060992 (response to fungicide)
GO:0071230 (cellular response to amino acid stimulus)
GO:0071359 (cellular response to dsRNA)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071375 (cellular response to peptide hormone stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071418 (cellular response to amine stimulus)

Target Cross References - Protein

canSAR P19490
IntAct P19490
UniProt P19490

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 2AWW 2G2L 3SAJ
CREDO 2AWW 2G2L 3SAJ
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