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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3746
Preferred Name 11-beta-hydroxysteroid dehydrogenase 2
Synonyms 11-DH2 | 11-HSD type II | 11-beta-HSD type II | 11-beta-HSD | 11-beta-HSD2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type II | Corticosteroid 11-beta-dehydrogenase isozyme 2 | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 | Short chain dehydrogenase/reductase family 9C member 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Corticosteroid 11-beta-dehydrogenase isozyme 2 SINGLE PROTEIN P80365

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3542430 11-beta-hydroxysteroid dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176387
Ensembl ENSG00000176387
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0003845 (11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity)
GO:0005496 (steroid binding)
GO:0016491 (oxidoreductase activity)
GO:0051287 (NAD binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0002017 (regulation of blood volume by renal aldosterone)
GO:0006704 (glucocorticoid biosynthetic process)
GO:0007565 (female pregnancy)
GO:0008211 (glucocorticoid metabolic process)
GO:0032094 (response to food)
GO:0032868 (response to insulin)
GO:0042493 (response to drug)
GO:0048545 (response to steroid hormone)
GO:0051384 (response to glucocorticoid)
GO:0055114 (oxidation-reduction process)
Wikipedia Corticosteroid_11-beta-dehydrogenase_isozyme_2

Target Cross References - Protein

canSAR P80365
CGD Cortisol 11-beta-ketoreductase deficiency
Human Protein Atlas ENSG00000176387
Open Targets ENSG00000176387
PharmGKB PA29477
Reactome R-HSA-194002 (Glucocorticoid biosynthesis.)
UniProt A7LB28 C5HTY7 P80365 Q13194 Q6P2G9 Q8N439 Q96QN8 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR020904 (Sc_DH/Rdtase_CS.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF00106 (adh_short)