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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3724
Target Type SINGLE PROTEIN
Preferred Name Lysophosphatidic acid receptor Edg-4
Synonyms EDG4 | LPA receptor 2 | LPA-2 | LPA2 | LPAR2 | Lysophosphatidic acid receptor 2 | Lysophosphatidic acid receptor Edg-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > edg receptor

Target Components

Component Description Relationship Accession
Lysophosphatidic acid receptor 2 SINGLE PROTEIN Q9HBW0

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000064547
Ensembl ENSG00000064547
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030139 (endocytic vesicle)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0008289 (lipid binding)
GO:0070915 (lysophosphatidic acid receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
Wikipedia LPAR2

Target Cross References - Protein

canSAR Q9HBW0
Human Protein Atlas ENSG00000064547
IntAct Q9HBW0
Guide to Pharmacology 273
Open Targets ENSG00000064547
PharmGKB PA162394202
Pharos Q9HBW0 (Tchem)
Reactome R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-419408 (Lysosphingolipid and LPA receptors.)
UniProt O00543 O43431 Q9HBW0

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR004065 (LPA_rcpt.)
IPR004066 (LPA_rcpt_EDG4.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 4P0C
CREDO 4P0C
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