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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3721
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2C8
Synonyms CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 | Cytochrome P450 IIC2 | Cytochrome P450 MP-12 | Cytochrome P450 MP-20 | Cytochrome P450 form 1 | S-mephenytoin 4-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2c > cytochrome p450 2c8

Target Components

Component Description Relationship Accession
Cytochrome P450 2C8 SINGLE PROTEIN P10632

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138115
Ensembl ENSG00000138115
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0034875 (caffeine oxidase activity)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO:0101020 (estrogen 16-alpha-hydroxylase activity)
GO Biological Process GO:0002933 (lipid hydroxylation)
GO:0006082 (organic acid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0017144 (drug metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0042738 (exogenous drug catabolic process)
GO:0055114 (oxidation-reduction process)
GO:0070989 (oxidative demethylation)
GO:0097267 (omega-hydroxylase P450 pathway)
Wikipedia CYP2C8

Target Cross References - Protein

canSAR P10632
CGD Rhabdomyolysis, cerivastatin-induced
Human Protein Atlas ENSG00000138115
IntAct P10632
Guide to Pharmacology 1325
Open Targets ENSG00000138115
PharmGKB PA125
Reactome R-HSA-211981 (Xenobiotics.)
R-HSA-211999 (CYP2E1 reactions.)
R-HSA-2142670 (Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).)
R-HSA-2142816 (Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).)
UniProt A8K9N8 B0AZN2 B7Z1F6 P10632 Q5VX93 Q8WWB1 Q9UCZ9

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 1PQ2 2NNH 2NNI 2NNJ 2VN0
CREDO 1PQ2 2NNH 2NNI 2NNJ 2VN0
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