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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3713020
Target Type SINGLE PROTEIN
Preferred Name Mucin-5AC
Synonyms Gastric mucin | LeB | Lewis B blood group antigen | MUC-5AC | MUC5AC | Major airway glycoprotein | Mucin-5 subtype AC, tracheobronchial | Mucin-5AC | Synonyms=MUC5 | TBM | Tracheobronchial mucin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Mucin-5AC SINGLE PROTEIN P98088

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2108708 YTTRIUM Y 90 CLIVATUZUMAB TETRAXETAN Mucin-5AC binding agent 3 PubMed
CHEMBL3301586 CLIVATUZUMAB TETRAXETAN Mucin-5AC binding agent 2 PubMed
CHEMBL1743013 ENSITUXIMAB Mucin-5AC other 1 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000215182 ENSG00000283158
Ensembl ENSG00000215182 ENSG00000283158
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005796 (Golgi lumen)
GO:0005886 (plasma membrane)
GO:0070062 (extracellular exosome)
GO:0070701 (mucus layer)
GO Molecular Function GO:0005201 (extracellular matrix structural constituent)
GO Biological Process GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0016266 (O-glycan processing)
GO:0048015 (phosphatidylinositol-mediated signaling)

Target Cross References - Protein

Human Protein Atlas ENSG00000215182 ENSG00000283158
IntAct P98088
Open Targets ENSG00000215182 ENSG00000283158
Reactome R-HSA-5083625 (Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).)
R-HSA-5083632 (Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).)
R-HSA-5083636 (Defective GALNT12 causes colorectal cancer 1 (CRCS1).)
R-HSA-5621480 (Dectin-2 family.)
R-HSA-913709 (O-linked glycosylation of mucins.)
R-HSA-977068 (Termination of O-glycan biosynthesis.)
UniProt A0A096LPK4 O60460 O76065 P98088 Q13792 Q14425 Q658Q1 Q7M4S5 Q8N4M9 Q8WWQ3 Q8WWQ4 Q8WWQ5

Target Cross References - Domain

InterPro IPR001007 (VWF_dom.)
IPR001846 (VWF_type-D.)
IPR002919 (TIL_dom.)
IPR006207 (Cys_knot_C.)
IPR014853 (Unchr_dom_Cys-rich.)
IPR025155 (WxxW_domain.)
IPR036084 (Ser_inhib-like_sf.)
Pfam PF00094 (VWD)
PF01826 (TIL)
PF08742 (C8)
PF13330 (Mucin2_WxxW)

Target Cross References - Structure

PDBe 5AJN 5AJO 5AJP
CREDO 5AJN 5AJO 5AJP
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