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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3713007
Target Type SINGLE PROTEIN
Preferred Name Interferon alpha-1/13
Synonyms IFN-alpha-1/13 | IFNA1 | IFNA13 | Interferon alpha-1/13 | Interferon alpha-D | LeIF D
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Interferon alpha-1/13 SINGLE PROTEIN P01562

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3856161 Interferon alpha PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2108407 FARALIMOMAB Interferon alpha-1/13 binding agent 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197919 ENSG00000233816
Ensembl ENSG00000197919 ENSG00000233816
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO Molecular Function GO:0005125 (cytokine activity)
GO:0005126 (cytokine receptor binding)
GO:0005132 (type I interferon receptor binding)
GO Biological Process GO:0002250 (adaptive immune response)
GO:0002286 (T cell activation involved in immune response)
GO:0002323 (natural killer cell activation involved in immune response)
GO:0006952 (defense response)
GO:0006959 (humoral immune response)
GO:0007596 (blood coagulation)
GO:0010469 (regulation of receptor activity)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030183 (B cell differentiation)
GO:0033141 (positive regulation of peptidyl-serine phosphorylation of STAT protein)
GO:0042100 (B cell proliferation)
GO:0043330 (response to exogenous dsRNA)
GO:0045087 (innate immune response)
GO:0051607 (defense response to virus)
GO:0060337 (type I interferon signaling pathway)
GO:0060338 (regulation of type I interferon-mediated signaling pathway)

Target Cross References - Protein

Human Protein Atlas ENSG00000197919 ENSG00000233816
IntAct P01562
Open Targets ENSG00000197919 ENSG00000233816
Reactome R-HSA-909733 (Interferon alpha/beta signaling.)
R-HSA-912694 (Regulation of IFNA signaling.)
R-HSA-933541 (TRAF6 mediated IRF7 activation.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt D4Q9M8 P01562 Q14605 Q2M1L8 Q52LB8 Q5VYQ2 Q7M4Q1 Q8WZ68 Q9UMJ3

Target Cross References - Domain

InterPro IPR000471 (Interferon_alpha/beta/delta.)
IPR009079 (4_helix_cytokine-like_core.)
Pfam PF00143 (Interferon)

Target Cross References - Structure

PDBe 3UX9
CREDO 3UX9
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