ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3710
Target Type SINGLE PROTEIN
Preferred Name Prostanoid EP3 receptor
Synonyms PGE receptor EP3 subtype | PGE2 receptor EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor EP3 subtype | Prostanoid EP3 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostaglandin E2 receptor EP3 subtype SINGLE PROTEIN P43115

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363068 Prostaglandin E2 receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL606 MISOPROSTOL Prostanoid EP3 receptor agonist 4 DailyMed ISBN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000050628
Ensembl ENSG00000050628
GO Cellular Component GO:0005635 (nuclear envelope)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004955 (prostaglandin receptor activity)
GO:0004957 (prostaglandin E receptor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0008219 (cell death)
GO:0014827 (intestine smooth muscle contraction)
GO:0031622 (positive regulation of fever generation)
GO:0060455 (negative regulation of gastric acid secretion)
Wikipedia Prostaglandin_E_receptor_3

Target Cross References - Protein

canSAR P43115
Human Protein Atlas ENSG00000050628
IntAct P43115
Guide to Pharmacology 342
Open Targets ENSG00000050628
PharmGKB PA288
Pharos P43115 (Tclin)
Reactome R-HSA-391908 (Prostanoid ligand receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt B0AZN4 B1AK19 B5BUP5 O00326 P43115 Q12943 Q12944 Q12945 Q147X8 Q16546 Q5CZ59 Q5CZ61 Q5CZ62 Q5CZ63 Q5CZ64

Target Cross References - Domain

InterPro IPR000265 (Prostglndn_EP3_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR001244 (Prostglndn_DP_rcpt.)
IPR001481 (EP3_rcpt_2.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
spacer
spacer