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Target Report Card

Target Name and Classification

Target ID CHEMBL3568
Target Type SINGLE PROTEIN
Preferred Name Nitric-oxide synthase, brain
Synonyms Constitutive NOS | N-NOS | NC-NOS | NOS type I | NOS1 | Neuronal NOS | Nitric oxide synthase, brain | Peptidyl-cysteine S-nitrosylase NOS1 | bNOS | nNOS
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Nitric oxide synthase, brain SINGLE PROTEIN P29475

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111405 Nitric-oxide synthase (endothelial and brain) SELECTIVITY GROUP
CHEMBL2096621 Nitric oxide sythases; iNOS & nNOS SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089250
Ensembl ENSG00000089250
GO Cellular Component GO:0001917 (photoreceptor inner segment)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0030018 (Z disc)
GO:0030315 (T-tubule)
GO:0032991 (macromolecular complex)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0042383 (sarcolemma)
GO:0042995 (cell projection)
GO:0043197 (dendritic spine)
GO:0045121 (membrane raft)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO:1990425 (ryanodine receptor complex)
GO Molecular Function GO:0003958 (NADPH-hemoprotein reductase activity)
GO:0004517 (nitric-oxide synthase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0010181 (FMN binding)
GO:0016491 (oxidoreductase activity)
GO:0017080 (sodium channel regulator activity)
GO:0020037 (heme binding)
GO:0034617 (tetrahydrobiopterin binding)
GO:0034618 (arginine binding)
GO:0044325 (ion channel binding)
GO:0046870 (cadmium ion binding)
GO:0046872 (metal ion binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0050661 (NADP binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0002028 (regulation of sodium ion transport)
GO:0006527 (arginine catabolic process)
GO:0006809 (nitric oxide biosynthetic process)
GO:0006941 (striated muscle contraction)
GO:0007263 (nitric oxide mediated signal transduction)
GO:0007520 (myoblast fusion)
GO:0009408 (response to heat)
GO:0010523 (negative regulation of calcium ion transport into cytosol)
GO:0018119 (peptidyl-cysteine S-nitrosylation)
GO:0031284 (positive regulation of guanylate cyclase activity)
GO:0033555 (multicellular organismal response to stress)
GO:0035066 (positive regulation of histone acetylation)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0042311 (vasodilation)
GO:0042738 (exogenous drug catabolic process)
GO:0043267 (negative regulation of potassium ion transport)
GO:0045454 (cell redox homeostasis)
GO:0045776 (negative regulation of blood pressure)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050767 (regulation of neurogenesis)
GO:0051346 (negative regulation of hydrolase activity)
GO:0051612 (negative regulation of serotonin uptake)
GO:0051926 (negative regulation of calcium ion transport)
GO:0055114 (oxidation-reduction process)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0060314 (regulation of ryanodine-sensitive calcium-release channel activity)
GO:0071363 (cellular response to growth factor stimulus)
GO:0098735 (positive regulation of the force of heart contraction)
GO:0098924 (retrograde trans-synaptic signaling by nitric oxide)
GO:0140196 (positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)
GO:1902307 (positive regulation of sodium ion transmembrane transport)
GO:1902514 (regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)
GO:1903779 (regulation of cardiac conduction)
Wikipedia NOS1

Target Cross References - Protein

canSAR P29475
Human Protein Atlas ENSG00000089250
IntAct P29475
Guide to Pharmacology 1251
Open Targets ENSG00000089250
PharmGKB PA252
Reactome R-HSA-1222556 (ROS, RNS production in phagocytes.)
R-HSA-392154 (Nitric oxide stimulates guanylate cyclase.)
R-HSA-5578775 (Ion homeostasis.)
UniProt E9PH30 O75713 P29475

Target Cross References - Domain

InterPro IPR001094 (Flavdoxin-like.)
IPR001433 (OxRdtase_FAD/NAD-bd.)
IPR001478 (PDZ.)
IPR001709 (Flavoprot_Pyr_Nucl_cyt_Rdtase.)
IPR003097 (FAD-binding_1.)
IPR004030 (NOS_N.)
IPR008254 (Flavodoxin/NO_synth.)
IPR012144 (NOS_euk.)
IPR017927 (Fd_Rdtase_FAD-bd.)
IPR017938 (Riboflavin_synthase-like_b-brl.)
IPR023173 (NADPH_Cyt_P450_Rdtase_alpha.)
IPR029039 (Flavoprotein-like_sf.)
IPR036034 (PDZ_sf.)
IPR036119 (NOS_N_sf.)
Pfam PF00175 (NAD_binding_1)
PF00258 (Flavodoxin_1)
PF00595 (PDZ)
PF00667 (FAD_binding_1)
PF02898 (NO_synthase)

Target Cross References - Structure

PDBe 4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5VUV 5VUW 5VUX 5VUY 5VUZ More...
CREDO 4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5VUV 5VUW 5VUX 5VUY 5VUZ More...
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