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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3563
Target Type SINGLE PROTEIN
Preferred Name Cruzipain
Synonyms Cruzaine | Cruzipain | Major cysteine proteinase
Organism Trypanosoma cruzi
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c1a family

Target Components

Component Description Relationship Accession
Cruzipain SINGLE PROTEIN P25779

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)

Target Cross References - Protein

canSAR P25779
UniProt P25779

Target Cross References - Domain

InterPro IPR000169 (Pept_cys_AS.)
IPR000668 (Peptidase_C1A_C.)
IPR013128 (Peptidase_C1A.)
IPR013201 (Prot_inhib_I29.)
IPR021981 (DUF3586.)
IPR025660 (Pept_his_AS.)
IPR025661 (Pept_asp_AS.)
Pfam PF00112 (Peptidase_C1)
PF08246 (Inhibitor_I29)
PF12131 (DUF3586)

Target Cross References - Structure

PDBe 1AIM 1EWL 1EWM 1EWO 1EWP 1F29 1F2A 1F2B 1F2C 1ME3 1ME4 1U9Q 2AIM 2OZ2 3HD3 3I06 3IUT 3KKU 3LXS 4KLB 4PI3 4QH6 4W5B 4W5C More...
CREDO 1AIM 1EWL 1EWM 1EWO 1EWP 1F29 1F2A 1F2B 1F2C 1ME3 1ME4 1U9Q 2AIM 2OZ2 3HD3 3I06 3IUT 3KKU 3LXS 4KLB 4PI3 4QH6 4W5B 4W5C More...
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