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Target Report Card

Target Name and Classification

Target ID CHEMBL3559691
Target Type PROTEIN FAMILY
Preferred Name Cyclin-dependent kinase
Synonyms 39 kDa protein kinase | ALS2CR7 | Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein | C-2K | CAK | CAK-kinase p42 | CAK1 | CCRK | CDC2 | CDC2-related protein kinase 5 | CDC2-related protein kinase 6 | CDC2-related protein kinase 7 | CDC28A | CDC2L | CDC2L1 | CDC2L4 | CDC2L5 | CDC2L6 | CDCH | CDK-activating kinase 1 | CDK-activating kinase p42 | CDK1 | CDK1 | CDK10 | CDK11 | CDK11 | CDK11B | CDK12 | CDK13 | CDK14 | CDK15 | CDK16 | CDK17 | CDK18 | CDK19 | CDK2 | CDK20 | CDK3 | CDK4 | CDK5 | CDK6 | CDK7 | CDK8 | CDK9 | CDKN1 | CDKN2 | CDKN3 | CDKN5 | CDKN6 | CDKN7 | CHED | CLK-1 | CRK7 | CRKRS | Cdc2-related kinase, arginine/serine-rich | Cell cycle-related kinase | Cell division control protein 2 homolog | Cell division cycle 2-like protein kinase 1 | Cell division cycle 2-like protein kinase 4 | Cell division cycle 2-like protein kinase 5 | Cell division cycle 2-like protein kinase 6 | Cell division cycle 2-related protein kinase 7 | Cell division protein kinase 1 | Cell division protein kinase 10 | Cell division protein kinase 11B | Cell division protein kinase 12 | Cell division protein kinase 13 | Cell division protein kinase 14 | Cell division protein kinase 15 | Cell division protein kinase 16 | Cell division protein kinase 17 | Cell division protein kinase 18 | Cell division protein kinase 19 | Cell division protein kinase 2 | Cell division protein kinase 20 | Cell division protein kinase 3 | Cell division protein kinase 4 | Cell division protein kinase 5 | Cell division protein kinase 6 | Cell division protein kinase 7 | Cell division protein kinase 8 | Cell division protein kinase 9 | Cholinesterase-related cell division controller | CrkRS | Cyclin-dependent kinase 1 | Cyclin-dependent kinase 10 | Cyclin-dependent kinase 11 | Cyclin-dependent kinase 11B | Cyclin-dependent kinase 12 | Cyclin-dependent kinase 13 | Cyclin-dependent kinase 14 | Cyclin-dependent kinase 15 | Cyclin-dependent kinase 16 | Cyclin-dependent kinase 17 | Cyclin-dependent kinase 18 | Cyclin-dependent kinase 19 | Cyclin-dependent kinase 2 | Cyclin-dependent kinase 20 | Cyclin-dependent kinase 3 | Cyclin-dependent kinase 4 | Cyclin-dependent kinase 6 | Cyclin-dependent kinase 7 | Cyclin-dependent kinase 8 | Cyclin-dependent kinase 9 | Cyclin-dependent protein kinase H | Cyclin-dependent-like kinase 5 | Cyclin-kinase-activating kinase p42 | Death-preventing kinase | Galactosyltransferase-associated protein kinase p58/GTA | KIAA0834 | KIAA0904 | KIAA1028 | KIAA1791 | MO15 | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | P34CDC2 | PCTAIRE-motif protein kinase 1 | PCTAIRE-motif protein kinase 2 | PCTAIRE-motif protein kinase 3 | PCTAIRE1 | PCTAIRE2 | PCTAIRE3 | PCTK1 | PCTK2 | PCTK3 | PFTK1 | PFTK2 | PITSLRE serine/threonine-protein kinase CDC2L1 | PITSLREA | PK58 | PSK-J3 | Protein kinase K35 | STK1 | Serine/threonine-protein kinase 1 | Serine/threonine-protein kinase ALS2CR7 | Serine/threonine-protein kinase PCTAIRE-1 | Serine/threonine-protein kinase PCTAIRE-2 | Serine/threonine-protein kinase PCTAIRE-3 | Serine/threonine-protein kinase PFTAIRE-1 | Serine/threonine-protein kinase PFTAIRE-2 | Serine/threonine-protein kinase PISSLRE | Serine/threonine-protein kinase PITALRE | Serine/threonine-protein kinase PLSTIRE | Serine/threonine-protein kinase PSSALRE | TAK | TFIIH basal transcription factor complex kinase subunit | TPKII catalytic subunit | Tat-associated kinase complex catalytic subunit | Tau protein kinase II catalytic subunit | hCDK12 | hCDK13 | hPFTAIRE1 | p33 protein kinase | p34 protein kinase | p39 Mo15 | p58 CLK-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase pitslre subfamily
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase taire subfamily
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdk8 subfamily
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdk7 subfamily
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdk9 subfamily
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdk5 subfamily
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdc2 subfamily
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase pftaire
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase pctaire

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 14 GROUP MEMBER O94921
Cyclin-dependent kinase 1 GROUP MEMBER P06493
Cyclin-dependent kinase 4 GROUP MEMBER P11802
Cyclin-dependent kinase 11B GROUP MEMBER P21127
Cyclin-dependent kinase 2 GROUP MEMBER P24941
Cyclin-dependent kinase 8 GROUP MEMBER P49336
Cyclin-dependent kinase 7 GROUP MEMBER P50613
Cyclin-dependent kinase 9 GROUP MEMBER P50750
Cyclin-dependent kinase 3 GROUP MEMBER Q00526
Cyclin-dependent kinase 6 GROUP MEMBER Q00534
Cyclin-dependent-like kinase 5 GROUP MEMBER Q00535
Cyclin-dependent kinase 16 GROUP MEMBER Q00536
Cyclin-dependent kinase 17 GROUP MEMBER Q00537
Cyclin-dependent kinase 18 GROUP MEMBER Q07002
Cyclin-dependent kinase 13 GROUP MEMBER Q14004
Cyclin-dependent kinase 10 GROUP MEMBER Q15131
Cyclin-dependent kinase 20 GROUP MEMBER Q8IZL9
Cyclin-dependent kinase 15 GROUP MEMBER Q96Q40
Cyclin-dependent kinase 19 GROUP MEMBER Q9BWU1
Cyclin-dependent kinase 12 GROUP MEMBER Q9NYV4

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111444 CDK3/cyclin E PROTEIN COMPLEX GROUP
CHEMBL2094127 Cyclin-dependent kinase 1/cyclin B PROTEIN COMPLEX
CHEMBL2111448 CDK6/cyclin D3 PROTEIN COMPLEX
CHEMBL2094126 Cyclin-dependent kinase 2/cyclin E PROTEIN COMPLEX
CHEMBL2094128 Cyclin-dependent kinase 2/cyclin A PROTEIN COMPLEX
CHEMBL2111455 CDK6/cyclin D1 PROTEIN COMPLEX
CHEMBL331 Cyclin-dependent kinase 4 SINGLE PROTEIN
CHEMBL4036 Cyclin-dependent kinase 5 SINGLE PROTEIN
CHEMBL4442 Cyclin-dependent kinase 3 SINGLE PROTEIN
CHEMBL3055 Cyclin-dependent kinase 7 SINGLE PROTEIN
CHEMBL301 Cyclin-dependent kinase 2 SINGLE PROTEIN
CHEMBL6002 Cell division cycle 2-like protein kinase 6 SINGLE PROTEIN
CHEMBL308 Cyclin-dependent kinase 1 SINGLE PROTEIN
CHEMBL3038517 CDK2/CDK4 PROTEIN FAMILY
CHEMBL3883323 Cyclin-C/Cyclin-dependent kinase 19 PROTEIN COMPLEX
CHEMBL5790 Serine/threonine-protein kinase PCTAIRE-2 SINGLE PROTEIN
CHEMBL5316 Serine/threonine-protein kinase PCTAIRE-3 SINGLE PROTEIN
CHEMBL5719 Cell division protein kinase 8 SINGLE PROTEIN
CHEMBL2111326 Cyclin-dependent kinase 2 and 4 (CDK2 and CDK4) SELECTIVITY GROUP
CHEMBL4597 Serine/threonine-protein kinase PCTAIRE-1 SINGLE PROTEIN
CHEMBL2111288 Cyclin-dependent kinase 7/ cyclin H PROTEIN COMPLEX
CHEMBL1795191 Cyclin-dependent kinase 10 SINGLE PROTEIN
CHEMBL1795192 Cyclin-dependent kinase 13 SINGLE PROTEIN
CHEMBL6162 Serine/threonine-protein kinase PFTAIRE-1 SINGLE PROTEIN
CHEMBL5808 PITSLRE serine/threonine-protein kinase CDC2L1 SINGLE PROTEIN
CHEMBL3885549 Cyclin-T1/Cyclin-dependent-like kinase 5 PROTEIN COMPLEX
CHEMBL3885548 Cyclin-A1/Cyclin-dependent kinase 4 PROTEIN COMPLEX
CHEMBL3885551 Cyclin-dependent kinase 1/G1/S-specific cyclin-D1 PROTEIN COMPLEX
CHEMBL1907601 Cyclin-dependent kinase 4/cyclin D1 PROTEIN COMPLEX
CHEMBL3885550 Cyclin-Y/Cyclin-dependent kinase 16 PROTEIN COMPLEX
CHEMBL1907600 Cyclin-dependent kinase 5/CDK5 activator 1 PROTEIN COMPLEX
CHEMBL3885553 Cyclin-dependent kinase 4/6 PROTEIN FAMILY
CHEMBL2095942 Cyclin-dependent kinase 4/cyclin D PROTEIN COMPLEX
CHEMBL3885552 Cyclin-dependent kinase 2/G1/S-specific cyclin-D1 PROTEIN COMPLEX
CHEMBL1907602 Cyclin-dependent kinase 1/cyclin B1 PROTEIN COMPLEX
CHEMBL3116 Cyclin-dependent kinase 9 SINGLE PROTEIN
CHEMBL1907605 Cyclin-dependent kinase 2/cyclin E1 PROTEIN COMPLEX
CHEMBL3885554 Cyclin-dependent kinase 4/G1/S-specific cyclin-E1 PROTEIN COMPLEX
CHEMBL3885556 Cyclin-dependent kinase 8/19 PROTEIN FAMILY
CHEMBL3301385 Cyclin-dependent kinase 4/cyclin D2 PROTEIN COMPLEX
CHEMBL2508 Cyclin-dependent kinase 6 SINGLE PROTEIN
CHEMBL3301386 CDK6/cyclin D2 PROTEIN COMPLEX
CHEMBL5856 Serine/threonine-protein kinase PFTAIRE-2 SINGLE PROTEIN
CHEMBL3038467 CDK1/Cyclin A PROTEIN COMPLEX
CHEMBL3038469 CDK2/Cyclin A PROTEIN COMPLEX
CHEMBL3038468 CDK1/Cyclin E PROTEIN COMPLEX
CHEMBL3038471 CDK3/Cyclin E PROTEIN COMPLEX
CHEMBL3038470 CDK2/Cyclin A1 PROTEIN COMPLEX
CHEMBL3038473 CDK7/Cyclin H/MNAT1 PROTEIN COMPLEX
CHEMBL2111389 CDK9/cyclin T1 PROTEIN COMPLEX
CHEMBL3038472 CDK4/Cyclin D3 PROTEIN COMPLEX
CHEMBL3038475 CDK9/Cyclin K PROTEIN COMPLEX
CHEMBL3038474 CDK8/Cyclin C PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL445813 AT-7519 Cyclin-dependent kinase inhibitor 2 PubMed PubMed
CHEMBL3544942 RONICICLIB Cyclin-dependent kinase inhibitor 2 PubMed
CHEMBL488436 AZD-5438 Cyclin-dependent kinase inhibitor 1 PubMed
CHEMBL1230607 PHA-793887 Cyclin-dependent kinase inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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