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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3559
Preferred Name Steryl-sulfatase
Synonyms ARSC1 | ASC | Arylsulfatase C | STS | Steroid sulfatase | Steryl-sulfatase | Steryl-sulfate sulfohydrolase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Steryl-sulfatase SINGLE PROTEIN P08842

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL286738 IROSUSTAT Steryl-sulfatase inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101846
Ensembl ENSG00000101846
GO Cellular Component GO:0005635 (nuclear envelope)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004773 (steryl-sulfatase activity)
GO:0008484 (sulfuric ester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0006706 (steroid catabolic process)
GO:0007565 (female pregnancy)
GO:0007611 (learning or memory)
GO:0008152 (metabolic process)
GO:0008202 (steroid metabolic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0008544 (epidermis development)
GO:0009268 (response to pH)
GO:0014070 (response to organic cyclic compound)
GO:0043434 (response to peptide hormone)
GO:0043588 (skin development)
GO:0043627 (response to estrogen)
GO:0043687 (post-translational protein modification)
Wikipedia Steroid_sulfatase

Target Cross References - Protein

canSAR P08842
CGD Steroid sulfatase deficiency
Human Protein Atlas ENSG00000101846
IntAct P08842
Open Targets ENSG00000101846
PharmGKB PA36225
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
R-HSA-1663150 (The activation of arylsulfatases.)
UniProt B2RA47 P08842

Target Cross References - Domain

InterPro IPR000917 (Sulfatase_N.)
IPR017849 (Alkaline_Pase-like_a/b/a.)
IPR017850 (Alkaline_phosphatase_core.)
IPR024607 (Sulfatase_CS.)
Pfam PF00884 (Sulfatase)

Target Cross References - Structure

PDBe 1P49