ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3522
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 17A1
Synonyms 17-alpha-hydroxyprogesterone aldolase | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450-C17 | Cytochrome P450c17 | S17AH | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 17 > cytochrome p450 family 17a > cytochrome p450 17a1

Target Components

Component Description Relationship Accession
Steroid 17-alpha-hydroxylase/17,20 lyase SINGLE PROTEIN P05093

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL254328 ABIRATERONE Cytochrome P450 17A1 inhibitor 4 PubMed PubMed PubMed PubMed PubMed
CHEMBL271227 ABIRATERONE ACETATE Cytochrome P450 17A1 inhibitor 4 FDA
CHEMBL1921976 ORTERONEL Cytochrome P450 17A1 inhibitor 3 PubMed
CHEMBL2105738 GALETERONE Cytochrome P450 17A1 inhibitor 3 Other PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000148795
Ensembl ENSG00000148795
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0030424 (axon)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004508 (steroid 17-alpha-monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016829 (lyase activity)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0047442 (17-alpha-hydroxyprogesterone aldolase activity)
GO Biological Process GO:0006694 (steroid biosynthetic process)
GO:0006702 (androgen biosynthetic process)
GO:0006704 (glucocorticoid biosynthetic process)
GO:0007548 (sex differentiation)
GO:0008202 (steroid metabolic process)
GO:0016125 (sterol metabolic process)
GO:0042446 (hormone biosynthetic process)
GO:0042448 (progesterone metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP17A1

Target Cross References - Protein

canSAR P05093
CGD Adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency
Human Protein Atlas ENSG00000148795
IntAct P05093
Guide to Pharmacology 1361
Open Targets ENSG00000148795
PharmGKB PA27090
Reactome R-HSA-193048 (Androgen biosynthesis.)
R-HSA-194002 (Glucocorticoid biosynthesis.)
R-HSA-211976 (Endogenous sterols.)
R-HSA-5579028 (Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5).)
UniProt P05093 Q5TZV7

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY 4NKZ 5IRQ 5IRV
CREDO 3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY 4NKZ 5IRQ 5IRV
spacer
spacer