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Target Report Card

Target Name and Classification

Target ID CHEMBL3503
Preferred Name Glutamate receptor ionotropic, AMPA 2
Synonyms AMPA-selective glutamate receptor 2 | GluA2 | GluR-2 | GluR-B | GluR-K2 | Glur2 | Glutamate receptor 2 | Glutamate receptor ionotropic, AMPA 2 | Gria2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > ampa receptor

Target Components

Component Description Relationship Accession
Glutamate receptor 2 SINGLE PROTEIN P19491

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883283 Glutamate receptor AMPA 1/2 PROTEIN COMPLEX
CHEMBL3883290 Glutamate receptor ionotropic, AMPA 2/3 PROTEIN COMPLEX
CHEMBL2093871 Glutamate receptor ionotropic, AMPA PROTEIN COMPLEX GROUP
CHEMBL3883292 Glutamate receptor AMPA 2/4 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008328 (ionotropic glutamate receptor complex)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0030672 (synaptic vesicle membrane)
GO:0032279 (asymmetric synapse)
GO:0032281 (AMPA glutamate receptor complex)
GO:0032839 (dendrite cytoplasm)
GO:0032991 (macromolecular complex)
GO:0042734 (presynaptic membrane)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0043204 (perikaryon)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0106003 (amyloid-beta complex)
GO Molecular Function GO:0000149 (SNARE binding)
GO:0001540 (beta-amyloid binding)
GO:0004970 (ionotropic glutamate receptor activity)
GO:0004971 (AMPA glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005246 (calcium channel regulator activity)
GO:0005515 (protein binding)
GO:0008092 (cytoskeletal protein binding)
GO:0015277 (kainate selective glutamate receptor activity)
GO:0019901 (protein kinase binding)
GO:0030165 (PDZ domain binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO:0051117 (ATPase binding)
GO Biological Process GO:0001919 (regulation of receptor recycling)
GO:0006811 (ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0010226 (response to lithium ion)
GO:0031623 (receptor internalization)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0045184 (establishment of protein localization)
GO:0050806 (positive regulation of synaptic transmission)
GO:0051262 (protein tetramerization)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:0060079 (excitatory postsynaptic potential)
GO:0060992 (response to fungicide)

Target Cross References - Protein

canSAR P19491
IntAct P19491
Guide to Pharmacology 445
UniProt P19491 Q9R174

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 1FTJ 1FTK 1FTL 1FTM 1FTO 1FW0 1GR2 1LB8 1LB9 1LBB 1LBC 1M5B 1M5C 1M5D 1M5E 1M5F 1MM6 1MM7 1MQD 1MQG 1MQH 1MQI 1MQJ 1MS7 More...
CREDO 1FTJ 1FTK 1FTL 1FTM 1FTO 1FW0 1GR2 1LB8 1LB9 1LBB 1LBC 1M5B 1M5C 1M5D 1M5E 1M5F 1MM6 1MM7 1MQD 1MQG 1MQH 1MQI 1MQJ 1MS7 More...