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Target Report Card

Target Name and Classification

Target ID CHEMBL3474
Preferred Name Phospholipase A2 group IIA
Synonyms GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-pancreatic secretory phospholipase A2 | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase 2A | Phospholipase A2, membrane associated | RASF-A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phospholipase A2, membrane associated SINGLE PROTEIN P14555

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2105659 VARESPLADIB METHYL Phospholipase A2 group IIA inhibitor 3 PubMed
CHEMBL148674 VARESPLADIB Phospholipase A2 group IIA inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000188257
Ensembl ENSG00000188257
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030141 (secretory granule)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004623 (phospholipase A2 activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0047498 (calcium-dependent phospholipase A2 activity)
GO:0102567 (phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine))
GO:0102568 (phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine))
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006644 (phospholipid metabolic process)
GO:0006654 (phosphatidic acid biosynthetic process)
GO:0010744 (positive regulation of macrophage derived foam cell differentiation)
GO:0016042 (lipid catabolic process)
GO:0019730 (antimicrobial humoral response)
GO:0034374 (low-density lipoprotein particle remodeling)
GO:0036148 (phosphatidylglycerol acyl-chain remodeling)
GO:0036149 (phosphatidylinositol acyl-chain remodeling)
GO:0036150 (phosphatidylserine acyl-chain remodeling)
GO:0036151 (phosphatidylcholine acyl-chain remodeling)
GO:0036152 (phosphatidylethanolamine acyl-chain remodeling)
GO:0046473 (phosphatidic acid metabolic process)
GO:0050482 (arachidonic acid secretion)
GO:0050729 (positive regulation of inflammatory response)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
Wikipedia PLA2G2A

Target Cross References - Protein

canSAR P14555
Human Protein Atlas ENSG00000188257
IntAct P14555
Guide to Pharmacology 1417
Open Targets ENSG00000188257
PharmGKB PA270
Reactome R-HSA-1482788 (Acyl chain remodelling of PC.)
R-HSA-1482801 (Acyl chain remodelling of PS.)
R-HSA-1482839 (Acyl chain remodelling of PE.)
R-HSA-1482922 (Acyl chain remodelling of PI.)
R-HSA-1482925 (Acyl chain remodelling of PG.)
R-HSA-1483166 (Synthesis of PA.)
R-HSA-6803157 (Antimicrobial peptides.)
UniProt A8K5I7 P14555 Q6DN24 Q6IBD9 Q9UCD2

Target Cross References - Domain

InterPro IPR001211 (PLipase_A2.)
IPR016090 (PLipase_A2_dom.)
IPR033112 (PLipase_A2_Asp_AS.)
IPR033113 (PLipase_A2_His_AS.)
IPR036444 (PLipase_A2_dom_sf.)
Pfam PF00068 (Phospholip_A2_1)

Target Cross References - Structure

PDBe 1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 3U8B 3U8D 3U8H 3U8I 5G3N
CREDO 1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 3U8B 3U8D 3U8H 3U8I 5G3N