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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3471
Target Type SINGLE PROTEIN
Preferred Name Human immunodeficiency virus type 1 integrase
Synonyms Integrase | pol
Organism Human immunodeficiency virus 1
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Integrase SINGLE PROTEIN Q7ZJM1

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL204656 ELVITEGRAVIR Human immunodeficiency virus type 1 integrase inhibitor 4 DailyMed
CHEMBL518520 RALTEGRAVIR POTASSIUM Human immunodeficiency virus type 1 integrase inhibitor 4 DailyMed
CHEMBL1213165 DOLUTEGRAVIR SODIUM Human immunodeficiency virus type 1 integrase inhibitor 4 DailyMed PubMed
CHEMBL3989866 BICTEGRAVIR Human immunodeficiency virus type 1 integrase inhibitor 4 FDA

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Molecular Function GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003824 (catalytic activity)
GO:0003964 (RNA-directed DNA polymerase activity)
GO:0004518 (nuclease activity)
GO:0004519 (endonuclease activity)
GO:0008270 (zinc ion binding)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006278 (RNA-dependent DNA biosynthetic process)
GO:0006310 (DNA recombination)
GO:0008152 (metabolic process)
GO:0015074 (DNA integration)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)

Target Cross References - Protein

canSAR Q7ZJM1
UniProt Q7ZJM1

Target Cross References - Domain

InterPro IPR001037 (Integrase_C_retrovir.)
IPR001584 (Integrase_cat-core.)
IPR003308 (Integrase_Zn-bd_dom_N.)
IPR012337 (RNaseH-like_sf.)
IPR017856 (Integrase-like_N.)
IPR036397 (RNaseH_sf.)
IPR036862 (Integrase_C_dom_sf_retrovir.)
Pfam PF00552 (IN_DBD_C)
PF00665 (rve)
PF02022 (Integrase_Zn)
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