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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3457
Target Type SINGLE PROTEIN
Preferred Name Kynurenine 3-monooxygenase
Synonyms Kmo | Kynurenine 3-hydroxylase | Kynurenine 3-monooxygenase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Kynurenine 3-monooxygenase SINGLE PROTEIN O88867

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004502 (kynurenine 3-monooxygenase activity)
GO:0016174 (NAD(P)H oxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0071949 (FAD binding)
GO Biological Process GO:0006569 (tryptophan catabolic process)
GO:0009435 (NAD biosynthetic process)
GO:0009651 (response to salt stress)
GO:0019363 (pyridine nucleotide biosynthetic process)
GO:0019441 (tryptophan catabolic process to kynurenine)
GO:0019674 (NAD metabolic process)
GO:0019805 (quinolinate biosynthetic process)
GO:0032496 (response to lipopolysaccharide)
GO:0044550 (secondary metabolite biosynthetic process)
GO:0055114 (oxidation-reduction process)
GO:0070189 (kynurenine metabolic process)
GO:0071347 (cellular response to interleukin-1)
GO:0097052 (L-kynurenine metabolic process)
GO:1901216 (positive regulation of neuron death)
GO:1903296 (positive regulation of glutamate secretion, neurotransmission)

Target Cross References - Protein

canSAR O88867
Reactome R-RNO-71240 (Tryptophan catabolism.)
UniProt O88867

Target Cross References - Domain

InterPro IPR002938 (FAD-bd.)
IPR027545 (Kynurenine_monooxygenase.)
IPR036188 (FAD/NAD-bd_sf.)
Pfam PF01494 (FAD_binding_3)
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