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Target Report Card

Target Name and Classification

Target ID CHEMBL3456
Preferred Name Progesterone receptor
Synonyms NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | Progesterone receptor
Organism Oryctolagus cuniculus
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group c > nuclear hormone receptor subfamily 3 group c member 3

Target Components

Component Description Relationship Accession
Progesterone receptor SINGLE PROTEIN P06186

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005496 (steroid binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0019899 (enzyme binding)
GO:0042802 (identical protein binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0051117 (ATPase binding)
GO Biological Process GO:0001542 (ovulation from ovarian follicle)
GO:0002070 (epithelial cell maturation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0010629 (negative regulation of gene expression)
GO:0030879 (mammary gland development)
GO:0038001 (paracrine signaling)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048286 (lung alveolus development)
GO:0050678 (regulation of epithelial cell proliferation)
GO:0050847 (progesterone receptor signaling pathway)
GO:0060748 (tertiary branching involved in mammary gland duct morphogenesis)

Target Cross References - Protein

canSAR P06186
UniProt P06186

Target Cross References - Domain

InterPro IPR000128 (Progest_rcpt.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF02161 (Prog_receptor)