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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL344
Target Type SINGLE PROTEIN
Preferred Name Melanin-concentrating hormone receptor 1
Synonyms G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1 | Melanin-concentrating hormone receptor 1 | SLC-1 | SLC1 | Somatostatin receptor-like protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > mch receptor

Target Components

Component Description Relationship Accession
Melanin-concentrating hormone receptor 1 SINGLE PROTEIN Q99705

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111437 Melanin-concentrating hormone receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000128285
Ensembl ENSG00000128285
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0060170 (ciliary membrane)
GO:0097730 (non-motile cilium)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005102 (receptor binding)
GO:0008022 (protein C-terminus binding)
GO:0008188 (neuropeptide receptor activity)
GO:0030273 (melanin-concentrating hormone receptor activity)
GO:0042562 (hormone binding)
GO Biological Process GO:0006091 (generation of precursor metabolites and energy)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007631 (feeding behavior)
GO:0051928 (positive regulation of calcium ion transport)
Wikipedia Melanin-concentrating_hormone_receptor_1

Target Cross References - Protein

canSAR Q99705
Human Protein Atlas ENSG00000128285
Guide to Pharmacology 280
Open Targets ENSG00000128285
PharmGKB PA28867
Pharos Q99705 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-5620922 (BBSome-mediated cargo-targeting to cilium.)
UniProt B2RBX6 Q5R3J1 Q96S47 Q99705 Q9BV08

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR004047 (MCH1_rcpt.)
IPR008361 (MCH_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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