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Target Report Card

Target Name and Classification

Target ID CHEMBL3429
Target Type SINGLE PROTEIN
Preferred Name Estrogen-related receptor alpha
Synonyms ERR-alpha | ERR1 | ESRL1 | ESRRA | Estrogen receptor-like 1 | Estrogen-related receptor alpha | NR3B1 | Nuclear receptor subfamily 3 group B member 1 | Steroid hormone receptor ERR1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group b > nuclear hormone receptor subfamily 3 group b member 1

Target Components

Component Description Relationship Accession
Steroid hormone receptor ERR1 SINGLE PROTEIN P11474

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173153
Ensembl ENSG00000173153
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0015630 (microtubule cytoskeleton)
GO:0045171 (intercellular bridge)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001078 (transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005496 (steroid binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0019904 (protein domain specific binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007005 (mitochondrion organization)
GO:0030278 (regulation of ossification)
GO:0030522 (intracellular receptor signaling pathway)
GO:0032355 (response to estradiol)
GO:0042127 (regulation of cell proliferation)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045667 (regulation of osteoblast differentiation)
GO:0045670 (regulation of osteoclast differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051216 (cartilage development)
GO:1900078 (positive regulation of cellular response to insulin stimulus)
Wikipedia Estrogen-related_receptor_alpha

Target Cross References - Protein

canSAR P11474
Human Protein Atlas ENSG00000173153
IntAct P11474
Guide to Pharmacology 622
Open Targets ENSG00000173153
PharmGKB PA27887
Pharos P11474 (Tchem)
Reactome R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-2151201 (Transcriptional activation of mitochondrial biogenesis.)
R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt P11474 Q14514

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR024178 (Oest_rcpt/oest-rel_rcp.)
IPR027289 (Oest-rel_rcp.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1XB7 2PJL 3D24 3K6P
CREDO 1XB7 2PJL 3D24 3K6P
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