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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3407319
Target Type SINGLE PROTEIN
Preferred Name Neurogenic locus notch homolog protein 3
Synonyms NOTCH3 | Neurogenic locus notch homolog protein 3 | Notch 3 extracellular truncation | Notch 3 intracellular domain | Notch 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Neurogenic locus notch homolog protein 3 SINGLE PROTEIN Q9UM47

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3301588 TAREXTUMAB Neurogenic locus notch homolog protein 3 inhibitor 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000074181
Ensembl ENSG00000074181
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0015629 (actin cytoskeleton)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0019899 (enzyme binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO:0045296 (cadherin binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007219 (Notch signaling pathway)
GO:0007221 (positive regulation of transcription of Notch receptor target)
GO:0007275 (multicellular organism development)
GO:0030154 (cell differentiation)
GO:0030900 (forebrain development)
GO:0035333 (Notch receptor processing, ligand-dependent)
GO:0045596 (negative regulation of cell differentiation)
GO:0045665 (negative regulation of neuron differentiation)
GO:0045746 (negative regulation of Notch signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0048663 (neuron fate commitment)
GO:0048844 (artery morphogenesis)
GO:0050793 (regulation of developmental process)
GO:0072104 (glomerular capillary formation)

Target Cross References - Protein

Human Protein Atlas ENSG00000074181
IntAct Q9UM47
Guide to Pharmacology 2860
Open Targets ENSG00000074181
Reactome R-HSA-1912399 (Pre-NOTCH Processing in the Endoplasmic Reticulum.)
R-HSA-1912408 (Pre-NOTCH Transcription and Translation.)
R-HSA-1912420 (Pre-NOTCH Processing in Golgi.)
R-HSA-350054 (Notch-HLH transcription pathway.)
R-HSA-5083630 (Defective LFNG causes SCDO3.)
R-HSA-9013507 (NOTCH3 Activation and Transmission of Signal to the Nucleus.)
R-HSA-9013508 (NOTCH3 Intracellular Domain Regulates Transcription.)
R-HSA-9017802 (Noncanonical activation of NOTCH3.)
UniProt Q9UEB3 Q9UM47 Q9UPL3 Q9Y6L8

Target Cross References - Domain

InterPro IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000742 (EGF-like_dom.)
IPR000800 (Notch_dom.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR002110 (Ankyrin_rpt.)
IPR008297 (Notch.)
IPR009030 (Growth_fac_rcpt_cys_sf.)
IPR010660 (Notch_NOD_dom.)
IPR011656 (Notch_NODP_dom.)
IPR013032 (EGF-like_CS.)
IPR018097 (EGF_Ca-bd_CS.)
IPR020683 (Ankyrin_rpt-contain_dom.)
IPR022331 (Notch_3.)
IPR024600 (DUF3454_notch.)
IPR035993 (Notch-like_dom_sf.)
IPR036770 (Ankyrin_rpt-contain_sf.)
Pfam PF00008 (EGF)
PF00066 (Notch)
PF06816 (NOD)
PF07645 (EGF_CA)
PF07684 (NODP)
PF11936 (DUF3454)
PF12661 (hEGF)
PF12796 (Ank_2)

Target Cross References - Structure

PDBe 4ZLP 5CZV 5CZX
CREDO 4ZLP 5CZV 5CZX
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