ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3403
Target Type SINGLE PROTEIN
Preferred Name Butyrylcholinesterase
Synonyms Bche | Carboxylic ester hydrolase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Carboxylic ester hydrolase SINGLE PROTEIN Q9JKC1

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111475 Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005615 (extracellular space)
GO:0005641 (nuclear envelope lumen)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0016020 (membrane)
GO Molecular Function GO:0003990 (acetylcholinesterase activity)
GO:0004104 (cholinesterase activity)
GO:0016787 (hydrolase activity)
GO:0033265 (choline binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0007584 (response to nutrient)
GO:0007612 (learning)
GO:0008285 (negative regulation of cell proliferation)
GO:0014016 (neuroblast differentiation)
GO:0019695 (choline metabolic process)
GO:0042493 (response to drug)
GO:0043279 (response to alkaloid)
GO:0050805 (negative regulation of synaptic transmission)
GO:0051384 (response to glucocorticoid)
GO:0051593 (response to folic acid)

Target Cross References - Protein

canSAR Q9JKC1
MICAD NBK23388 (Butyrylcholinesterase (BChE, BuChE))
NBK23441 (Butyrylcholinesterase)
Reactome R-RNO-112311 (Neurotransmitter clearance.)
R-RNO-1483191 (Synthesis of PC.)
R-RNO-422085 (Synthesis, secretion, and deacylation of Ghrelin.)
UniProt F1LQK0 Q9JKC1

Target Cross References - Domain

InterPro IPR000997 (Cholinesterase.)
IPR002018 (CarbesteraseB.)
IPR014788 (AChE_tetra.)
IPR019819 (Carboxylesterase_B_CS.)
IPR019826 (Carboxylesterase_B_AS.)
IPR029058 (AB_hydrolase.)
Pfam PF00135 (COesterase)
PF08674 (AChE_tetra)
spacer
spacer