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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3371
Preferred Name Serotonin 6 (5-HT6) receptor
Synonyms 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | HTR6 | Serotonin receptor 6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 6 SINGLE PROTEIN P50406

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096904 Serotonin (5-HT) receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1083390 INTEPIRDINE Serotonin 6 (5-HT6) receptor antagonist 3 PubMed
CHEMBL3286580 IDALOPIRDINE Serotonin 6 (5-HT6) receptor antagonist 3 Other PubMed
CHEMBL2103880 CERLAPIRDINE Serotonin 6 (5-HT6) receptor antagonist 2 PubMed
CHEMBL3545344 PF-05212377 Serotonin 6 (5-HT6) receptor antagonist 2 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000158748
Ensembl ENSG00000158748
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005929 (cilium)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004969 (histamine receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0005515 (protein binding)
GO:0030594 (neurotransmitter receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007268 (chemical synaptic transmission)
GO:0021795 (cerebral cortex cell migration)
GO:0032008 (positive regulation of TOR signaling)
GO:0098664 (G-protein coupled serotonin receptor signaling pathway)
Wikipedia 5-HT6_receptor

Target Cross References - Protein

canSAR P50406
Human Protein Atlas ENSG00000158748
IntAct P50406
Guide to Pharmacology 11
Open Targets ENSG00000158748
PharmGKB PA29560
Pharos P50406 (Tchem)
Reactome R-HSA-390666 (Serotonin receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt P50406 Q13640 Q5TGZ1

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR002232 (5HT6_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)