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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3369
Target Type SINGLE PROTEIN
Preferred Name Neprilysin
Synonyms Atriopeptidase | CD_antigen=CD10 | Enkephalinase | Mme | NEP | Neprilysin | Neutral endopeptidase 24.11 | Neutral endopeptidase | SFE | Skin fibroblast elastase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m13 family

Target Components

Component Description Relationship Accession
Neprilysin SINGLE PROTEIN P07861

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005903 (brush border)
GO:0008021 (synaptic vesicle)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0044306 (neuron projection terminus)
GO:0045202 (synapse)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004222 (metalloendopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008238 (exopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001822 (kidney development)
GO:0006508 (proteolysis)
GO:0006518 (peptide metabolic process)
GO:0019233 (sensory perception of pain)
GO:0046449 (creatinine metabolic process)
GO:0050435 (beta-amyloid metabolic process)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071492 (cellular response to UV-A)
GO:0071493 (cellular response to UV-B)
GO:0090399 (replicative senescence)
GO:0097242 (amyloid-beta clearance)

Target Cross References - Protein

canSAR P07861
Reactome R-RNO-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
R-RNO-6798695 (Neutrophil degranulation.)
UniProt P07861

Target Cross References - Domain

InterPro IPR000718 (Peptidase_M13.)
IPR008753 (Peptidase_M13_N.)
IPR018497 (Peptidase_M13_C.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR029727 (MME/CD10/NEP.)
Pfam PF01431 (Peptidase_M13)
PF05649 (Peptidase_M13_N)
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