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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL3368
Target Type SINGLE PROTEIN
Preferred Name Glucocorticoid receptor
Synonyms Glucocorticoid receptor | Grl | Nr3c1 | Nuclear receptor subfamily 3 group C member 1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group c > nuclear hormone receptor subfamily 3 group c member 1

Target Components

Component Description Relationship Accession
Glucocorticoid receptor SINGLE PROTEIN P06536

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005815 (microtubule organizing center)
GO:0005819 (spindle)
GO:0005856 (cytoskeleton)
GO:0014069 (postsynaptic density)
GO:0016607 (nuclear speck)
GO:0032991 (macromolecular complex)
GO:0043005 (neuron projection)
GO:0043197 (dendritic spine)
GO Molecular Function GO:0001012 (RNA polymerase II regulatory region DNA binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004883 (glucocorticoid receptor activity)
GO:0005496 (steroid binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0030544 (Hsp70 protein binding)
GO:0030971 (receptor tyrosine kinase binding)
GO:0031072 (heat shock protein binding)
GO:0038051 (glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity)
GO:0042562 (hormone binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0046983 (protein dimerization activity)
GO:0051879 (Hsp90 protein binding)
GO:1990239 (steroid hormone binding)
GO Biological Process GO:0006325 (chromatin organization)
GO:0006338 (chromatin remodeling)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007420 (brain development)
GO:0007565 (female pregnancy)
GO:0007568 (aging)
GO:0007623 (circadian rhythm)
GO:0008209 (androgen metabolic process)
GO:0009314 (response to radiation)
GO:0010906 (regulation of glucose metabolic process)
GO:0014049 (positive regulation of glutamate secretion)
GO:0014823 (response to activity)
GO:0014854 (response to inactivity)
GO:0014889 (muscle atrophy)
GO:0030324 (lung development)
GO:0031914 (negative regulation of synaptic plasticity)
GO:0032868 (response to insulin)
GO:0042127 (regulation of cell proliferation)
GO:0042921 (glucocorticoid receptor signaling pathway)
GO:0043116 (negative regulation of vascular permeability)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043402 (glucocorticoid mediated signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046685 (response to arsenic-containing substance)
GO:0046689 (response to mercury ion)
GO:0048096 (chromatin-mediated maintenance of transcription)
GO:0051412 (response to corticosterone)
GO:0051592 (response to calcium ion)
GO:0051602 (response to electrical stimulus)
GO:0060999 (positive regulation of dendritic spine development)
GO:0061051 (positive regulation of cell growth involved in cardiac muscle cell development)
GO:0071286 (cellular response to magnesium ion)
GO:0071383 (cellular response to steroid hormone stimulus)
GO:0071385 (cellular response to glucocorticoid stimulus)
GO:0071548 (response to dexamethasone)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:2000324 (positive regulation of glucocorticoid receptor signaling pathway)

Target Cross References - Protein

canSAR P06536
IntAct P06536
MICAD NBK22972 (Glucocorticoid receptor)
NBK23662 (Glucocorticoid receptors)
UniProt O08624 P06536 Q8R463 Q8R5J0

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001409 (Glcrtcd_rcpt.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF02155 (GCR)

Target Cross References - Structure

PDBe 1GLU 1LAT 1R4O 1R4R 3FYL 3G6P 3G6Q 3G6R 3G6T 3G6U 3G8U 3G8X 3G97 3G99 3G9I 3G9J 3G9M 3G9O 3G9P
CREDO 1GLU 1LAT 1R4O 1R4R 3FYL 3G6P 3G6Q 3G6R 3G6T 3G6U 3G8U 3G8X 3G97 3G99 3G9I 3G9J 3G9M 3G9O 3G9P
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