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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3367
Target Type SINGLE PROTEIN
Preferred Name Methionyl-tRNA synthetase
Synonyms MetRS | Methionine--tRNA ligase | Methionyl-tRNA synthetase | metG
Organism Escherichia coli K-12
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Methionine--tRNA ligase SINGLE PROTEIN P00959

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO Molecular Function GO:0000049 (tRNA binding)
GO:0000166 (nucleotide binding)
GO:0003723 (RNA binding)
GO:0004812 (aminoacyl-tRNA ligase activity)
GO:0004825 (methionine-tRNA ligase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016874 (ligase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006412 (translation)
GO:0006418 (tRNA aminoacylation for protein translation)
GO:0006431 (methionyl-tRNA aminoacylation)

Target Cross References - Protein

canSAR P00959
IntAct P00959
UniProt P00959 Q2MAW4

Target Cross References - Domain

InterPro IPR001412 (aa-tRNA-synth_I_CS.)
IPR002547 (tRNA-bd_dom.)
IPR004495 (Met-tRNA-synth_bsu_C.)
IPR009080 (tRNAsynth_Ia_anticodon-bd.)
IPR012340 (NA-bd_OB-fold.)
IPR014729 (Rossmann-like_a/b/a_fold.)
IPR014758 (Met-tRNA_synth.)
IPR015413 (Methionyl/Leucyl_tRNA_Synth.)
IPR023458 (Met-tRNA_ligase_1.)
IPR029038 (MetRS_Zn.)
IPR033911 (MetRS_core.)
Pfam PF01588 (tRNA_bind)
PF09334 (tRNA-synt_1g)

Target Cross References - Structure

PDBe 1F4L 1P7P 1PFU 1PFV 1PFW 1PFY 1PG0 1PG2 1QQT 3H97 3H99 3H9B 3H9C
CREDO 1F4L 1P7P 1PFU 1PFV 1PFW 1PFY 1PG0 1PG2 1QQT 3H97 3H99 3H9B 3H9C
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