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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL3361
Target Type SINGLE PROTEIN
Preferred Name Dopamine D4 receptor
Synonyms D(2C) dopamine receptor | D(4) dopamine receptor | Dopamine D4 receptor | Drd4
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(4) dopamine receptor SINGLE PROTEIN P30729

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093868 Dopamine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005938 (cell cortex)
GO:0012506 (vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0043679 (axon terminus)
GO Molecular Function GO:0001591 (dopamine neurotransmitter receptor activity, coupled via Gi/Go)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0035240 (dopamine binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007195 (adenylate cyclase-inhibiting dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007614 (short-term memory)
GO:0007623 (circadian rhythm)
GO:0007626 (locomotory behavior)
GO:0008306 (associative learning)
GO:0008355 (olfactory learning)
GO:0009648 (photoperiodism)
GO:0042752 (regulation of circadian rhythm)
GO:0046928 (regulation of neurotransmitter secretion)
GO:0048511 (rhythmic process)
GO:0048545 (response to steroid hormone)
GO:0050804 (modulation of synaptic transmission)
GO:0050848 (regulation of calcium-mediated signaling)
GO:0060041 (retina development in camera-type eye)
GO:0060406 (positive regulation of penile erection)
GO:1904706 (negative regulation of vascular smooth muscle cell proliferation)
GO:1904753 (negative regulation of vascular associated smooth muscle cell migration)
GO:2000463 (positive regulation of excitatory postsynaptic potential)

Target Cross References - Protein

canSAR P30729
IntAct P30729
Guide to Pharmacology 217
MICAD NBK23025 (Dopamine D4 receptors)
UniProt P30729 Q62610

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR002185 (Dopamine_D4_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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