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Target Report Card

Target Name and Classification

Target ID CHEMBL335
Preferred Name Protein-tyrosine phosphatase 1B
Synonyms PTP-1B | PTP1B | PTPN1 | Protein-tyrosine phosphatase 1B | Tyrosine-protein phosphatase non-receptor type 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > tyrosine protein phosphatase

Target Components

Component Description Relationship Accession
Tyrosine-protein phosphatase non-receptor type 1 SINGLE PROTEIN P18031

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196396
Ensembl ENSG00000196396
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005769 (early endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0097443 (sorting endosome)
GO:0098554 (cytoplasmic side of endoplasmic reticulum membrane)
GO Molecular Function GO:0003723 (RNA binding)
GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0005158 (insulin receptor binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0030971 (receptor tyrosine kinase binding)
GO:0045296 (cadherin binding)
GO:0046875 (ephrin receptor binding)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0006470 (protein dephosphorylation)
GO:0006987 (activation of signaling protein activity involved in unfolded protein response)
GO:0007257 (activation of JUN kinase activity)
GO:0008286 (insulin receptor signaling pathway)
GO:0009966 (regulation of signal transduction)
GO:0009968 (negative regulation of signal transduction)
GO:0016311 (dephosphorylation)
GO:0030100 (regulation of endocytosis)
GO:0030948 (negative regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0030968 (endoplasmic reticulum unfolded protein response)
GO:0031532 (actin cytoskeleton reorganization)
GO:0033157 (regulation of intracellular protein transport)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0035791 (platelet-derived growth factor receptor-beta signaling pathway)
GO:0036498 (IRE1-mediated unfolded protein response)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0046626 (regulation of insulin receptor signaling pathway)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0060338 (regulation of type I interferon-mediated signaling pathway)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:1902202 (regulation of hepatocyte growth factor receptor signaling pathway)
GO:1902236 (negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)
GO:1903896 (positive regulation of IRE1-mediated unfolded protein response)
GO:1903898 (negative regulation of PERK-mediated unfolded protein response)
GO:1990264 (peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)
GO:2000646 (positive regulation of receptor catabolic process)
Wikipedia PTPN1

Target Cross References - Protein

canSAR P18031
Human Protein Atlas ENSG00000196396
IntAct P18031
Open Targets ENSG00000196396
PharmGKB PA33985
Reactome R-HSA-354192 (Integrin alphaIIb beta3 signaling.)
R-HSA-6807004 (Negative regulation of MET activity.)
R-HSA-877312 (Regulation of IFNG signaling.)
R-HSA-8849472 (PTK6 Down-Regulation.)
R-HSA-912694 (Regulation of IFNA signaling.)
R-HSA-982772 (Growth hormone receptor signaling.)
UniProt P18031 Q5TGD8 Q9BQV9 Q9NQQ4

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR003595 (Tyr_Pase_cat.)
IPR012265 (Ptpn1/Ptpn2.)
IPR016130 (Tyr_Pase_AS.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00102 (Y_phosphatase)

Target Cross References - Structure

PDBe 1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV More...
CREDO 1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV More...