ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL3310
Preferred Name Histone deacetylase 11
Synonyms HD11 | HDAC11 | Histone deacetylase 11
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iv

Target Components

Component Description Relationship Accession
Histone deacetylase 11 SINGLE PROTEIN Q96DB2

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL272980 MOCETINOSTAT Histone deacetylase 11 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163517
Ensembl ENSG00000163517
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004407 (histone deacetylase activity)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO Biological Process GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0014003 (oligodendrocyte development)
GO:0016575 (histone deacetylation)
GO:0070932 (histone H3 deacetylation)
Wikipedia HDAC11

Target Cross References - Protein

canSAR Q96DB2
Human Protein Atlas ENSG00000163517
IntAct Q96DB2
Guide to Pharmacology 2615
Open Targets ENSG00000163517
PharmGKB PA38793
Reactome R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
UniProt B4DDK1 Q96DB2 Q9H6I7 Q9H6X3 Q9NTC9

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR023696 (Ureohydrolase_dom_sf.)
IPR023801 (His_deacetylse_dom.)
IPR037138 (His_deacetylse_dom_sf.)
Pfam PF00850 (Hist_deacetyl)