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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3308
Preferred Name Caspase-6
Synonyms Apoptotic protease Mch-2 | CASP-6 | CASP6 | Caspase-6 subunit p11 | Caspase-6 subunit p18 | Caspase-6 | MCH2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-6 SINGLE PROTEIN P55212

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138794
Ensembl ENSG00000138794
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042802 (identical protein binding)
GO:0097200 (cysteine-type endopeptidase activity involved in execution phase of apoptosis)
GO Biological Process GO:0006508 (proteolysis)
GO:0006915 (apoptotic process)
GO:0030855 (epithelial cell differentiation)
GO:0042981 (regulation of apoptotic process)
GO:0072734 (cellular response to staurosporine)
GO:0097194 (execution phase of apoptosis)
Wikipedia Caspase_6

Target Cross References - Protein

canSAR P55212
Human Protein Atlas ENSG00000138794
IntAct P55212
Guide to Pharmacology 1622
Open Targets ENSG00000138794
PharmGKB PA26090
Reactome R-HSA-111465 (Apoptotic cleavage of cellular proteins.)
R-HSA-264870 (Caspase-mediated cleavage of cytoskeletal proteins.)
R-HSA-352238 (Breakdown of the nuclear lamina.)
R-HSA-6803207 (TP53 Regulates Transcription of Caspase Activators and Caspases.)
UniProt P55212 Q9BQE7

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_p20.)
IPR002138 (Pept_C14_p10.)
IPR015917 (Pept_C14A.)
IPR016129 (Caspase_his_AS.)
IPR029030 (Caspase-like_dom_sf.)
IPR033139 (Caspase_cys_AS.)
IPR037554 (Caspase_6.)

Target Cross References - Structure

PDBe 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN
CREDO 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN