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Target Report Card

Target Name and Classification

Target ID CHEMBL3286
Preferred Name Urokinase-type plasminogen activator
Synonyms PLAU | U-plasminogen activator | Urokinase-type plasminogen activator | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | uPA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Urokinase-type plasminogen activator SINGLE PROTEIN P00749

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111379 Thrombin and urokinase-type plasminogen activator SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000122861
Ensembl ENSG00000122861
GO Cellular Component GO:0009986 (cell surface)
GO:0005615 (extracellular space)
GO:0005925 (focal adhesion)
GO:0070062 (extracellular exosome)
GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO Biological Process GO:0006935 (chemotaxis)
GO:0071333 (cellular response to glucose stimulus)
GO:0071456 (cellular response to hypoxia)
GO:0007165 (signal transduction)
GO:0007596 (blood coagulation)
GO:0014910 (regulation of smooth muscle cell migration)
GO:0072734 (cellular response to staurosporine)
GO:0043403 (skeletal muscle tissue regeneration)
GO:0010469 (regulation of receptor activity)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:2000097 (regulation of smooth muscle cell-matrix adhesion)
GO:0008284 (positive regulation of cell proliferation)
GO:0035729 (cellular response to hepatocyte growth factor stimulus)
GO:0006508 (proteolysis)
GO:0007283 (spermatogenesis)
GO:0031639 (plasminogen activation)
GO:0033628 (regulation of cell adhesion mediated by integrin)
GO:0060279 (positive regulation of ovulation)
GO:0070997 (neuron death)
GO:2000345 (regulation of hepatocyte proliferation)
GO:0001525 (angiogenesis)
GO:0007566 (embryo implantation)
GO:0014909 (smooth muscle cell migration)
GO:0042730 (fibrinolysis)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:0014823 (response to activity)
GO:0055093 (response to hyperoxia)
GO:0061041 (regulation of wound healing)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071498 (cellular response to fluid shear stress)
Wikipedia PLAU

Target Cross References - Protein

canSAR P00749
CGD Quebec platelet disorder
Human Protein Atlas ENSG00000122861
IntAct P00749
Guide to Pharmacology 2393 (plasminogen activator, urokinase)
PharmGKB PA33382
UniProt Q15844 B4DPZ2 P00749 Q16618 Q53XS3 Q5SWW9 Q969W6

Target Cross References - Domain

InterPro IPR001314 (Peptidase_S1A.)
IPR018056 (Kringle_CS.)
IPR000001 (Kringle.)
IPR000742 (EGF-like_dom.)
IPR001254 (Trypsin_dom.)
IPR009003 (Peptidase_S1_PA.)
IPR013806 (Kringle-like.)
IPR013032 (EGF-like_CS.)
IPR018114 (Peptidase_S1_AS.)
Pfam PF00089 (Trypsin)
PF00051 (Kringle)

Target Cross References - Structure

PDBe 1GI7 1GJ7 1OWD 1OWI 1SC8 4FU7 4JK5 4OS2 4OS6 1C5Y 1C5Z 1O5B 1W12 1W14 2FD6 2I9A 2VIN 2VIP 2VIV 3OY6 4DVA 4FUB 4FUH 4JNL More...
CREDO 1GI7 1GJ7 1OWD 1OWI 1SC8 4FU7 4JK5 4OS2 4OS6 1C5Y 1C5Z 1O5B 1W12 1W14 2FD6 2I9A 2VIN 2VIP 2VIV 3OY6 4DVA 4FUB 4FUH 4JNL More...