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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3286
Preferred Name Urokinase-type plasminogen activator
Synonyms PLAU | U-plasminogen activator | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator | uPA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Urokinase-type plasminogen activator SINGLE PROTEIN P00749

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883324 Urokinase-type plasminogen activator/surface receptor PROTEIN-PROTEIN INTERACTION
CHEMBL2111379 Thrombin and urokinase-type plasminogen activator SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000122861
Ensembl ENSG00000122861
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0035579 (specific granule membrane)
GO:0070062 (extracellular exosome)
GO:0070821 (tertiary granule membrane)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006508 (proteolysis)
GO:0006935 (chemotaxis)
GO:0007165 (signal transduction)
GO:0007596 (blood coagulation)
GO:0007599 (hemostasis)
GO:0010469 (regulation of receptor activity)
GO:0014909 (smooth muscle cell migration)
GO:0014910 (regulation of smooth muscle cell migration)
GO:0030335 (positive regulation of cell migration)
GO:0031639 (plasminogen activation)
GO:0033628 (regulation of cell adhesion mediated by integrin)
GO:0042127 (regulation of cell proliferation)
GO:0042730 (fibrinolysis)
GO:0043312 (neutrophil degranulation)
GO:0061041 (regulation of wound healing)
GO:2000097 (regulation of smooth muscle cell-matrix adhesion)
Wikipedia PLAU

Target Cross References - Protein

canSAR P00749
CGD Quebec platelet disorder
Human Protein Atlas ENSG00000122861
IntAct P00749
Guide to Pharmacology 2393
Open Targets ENSG00000122861
PharmGKB PA33382
Reactome R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-75205 (Dissolution of Fibrin Clot.)
UniProt B4DPZ2 P00749 Q15844 Q16618 Q53XS3 Q5SWW9 Q969W6

Target Cross References - Domain

InterPro IPR000001 (Kringle.)
IPR000742 (EGF-like_dom.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR013032 (EGF-like_CS.)
IPR013806 (Kringle-like.)
IPR018056 (Kringle_CS.)
IPR034814 (Urokinase.)
Pfam PF00051 (Kringle)
PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1LMW 1O3P 1O5A 1O5B 1O5C More...
CREDO 1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1LMW 1O3P 1O5A 1O5B 1O5C More...