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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3272
Target Type SINGLE PROTEIN
Preferred Name Cathepsin L2
Synonyms CATL2 | CTSL2 | CTSU | CTSV | Cathepsin L2 | Cathepsin U | Cathepsin V
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c1a family

Target Components

Component Description Relationship Accession
Cathepsin L2 SINGLE PROTEIN O60911

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111361 Cathepsin (V and K) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136943
Ensembl ENSG00000136943
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005773 (vacuole)
GO:0005902 (microvillus)
GO:0009897 (external side of plasma membrane)
GO:0030141 (secretory granule)
GO:0031410 (cytoplasmic vesicle)
GO:0043005 (neuron projection)
GO:0043202 (lysosomal lumen)
GO:0043204 (perikaryon)
GO:0045177 (apical part of cell)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0016807 (cysteine-type carboxypeptidase activity)
GO:0030984 (kininogen binding)
GO:0042277 (peptide binding)
GO:0042393 (histone binding)
GO:0044877 (macromolecular complex binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007154 (cell communication)
GO:0007283 (spermatogenesis)
GO:0008584 (male gonad development)
GO:0009267 (cellular response to starvation)
GO:0009749 (response to glucose)
GO:0010259 (multicellular organism aging)
GO:0010839 (negative regulation of keratinocyte proliferation)
GO:0014070 (response to organic cyclic compound)
GO:0016485 (protein processing)
GO:0016540 (protein autoprocessing)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0021675 (nerve development)
GO:0022617 (extracellular matrix disassembly)
GO:0031069 (hair follicle morphogenesis)
GO:0034698 (response to gonadotropin)
GO:0045616 (regulation of keratinocyte differentiation)
GO:0046697 (decidualization)
GO:0048102 (autophagic cell death)
GO:0051384 (response to glucocorticoid)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0060008 (Sertoli cell differentiation)
GO:1990834 (response to odorant)
GO:2000249 (regulation of actin cytoskeleton reorganization)
Wikipedia Cathepsin_L2

Target Cross References - Protein

canSAR O60911
Human Protein Atlas ENSG00000136943
IntAct O60911
Guide to Pharmacology 2352
Open Targets ENSG00000136943
PharmGKB PA27036
Reactome R-HSA-1236977 (Endosomal/Vacuolar pathway.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-1679131 (Trafficking and processing of endosomal TLR.)
R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-8939242 (RUNX1 regulates transcription of genes involved in differentiation of keratinocytes.)
UniProt O60233 O60911 Q2TB86 Q5T1U0

Target Cross References - Domain

InterPro IPR000169 (Pept_cys_AS.)
IPR000668 (Peptidase_C1A_C.)
IPR013128 (Peptidase_C1A.)
IPR013201 (Prot_inhib_I29.)
IPR025660 (Pept_his_AS.)
IPR025661 (Pept_asp_AS.)
Pfam PF00112 (Peptidase_C1)
PF08246 (Inhibitor_I29)

Target Cross References - Structure

PDBe 1FH0 3H6S 3KFQ
CREDO 1FH0 3H6S 3KFQ
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