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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3250
Preferred Name Lysophosphatidic acid receptor Edg-7
Synonyms EDG7 | LPA receptor 3 | LPA-3 | LPA3 | LPAR3 | Lysophosphatidic acid receptor 3 | Lysophosphatidic acid receptor Edg-7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > edg receptor

Target Components

Component Description Relationship Accession
Lysophosphatidic acid receptor 3 SINGLE PROTEIN Q9UBY5

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885601 Lysophosphatidic acid receptor 1/3 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171517
Ensembl ENSG00000171517
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005543 (phospholipid binding)
GO:0008289 (lipid binding)
GO:0070915 (lysophosphatidic acid receptor activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007268 (chemical synaptic transmission)
GO:0032060 (bleb assembly)
GO:0043410 (positive regulation of MAPK cascade)
GO:0048672 (positive regulation of collateral sprouting)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051928 (positive regulation of calcium ion transport)
Wikipedia LPAR3

Target Cross References - Protein

Human Protein Atlas ENSG00000171517
IntAct Q9UBY5
Guide to Pharmacology 274
Open Targets ENSG00000171517
PharmGKB PA162394213
Pharos Q9UBY5 (Tchem)
Reactome R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-419408 (Lysosphingolipid and LPA receptors.)
UniProt A0AVA3 Q9UBY5

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR004065 (LPA_rcpt.)
IPR005385 (LPA_rcpt_EDG7.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)