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Target Report Card

Target Name and Classification

Target ID CHEMBL3247
Preferred Name HMG-CoA reductase
Synonyms 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMG-CoA reductase | Hmgcr
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
3-hydroxy-3-methylglutaryl-coenzyme A reductase SINGLE PROTEIN P51639

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005778 (peroxisomal membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004420 (hydroxymethylglutaryl-CoA reductase (NADPH) activity)
GO:0016491 (oxidoreductase activity)
GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
GO:0042282 (hydroxymethylglutaryl-CoA reductase activity)
GO:0042803 (protein homodimerization activity)
GO:0050661 (NADP binding)
GO:0050662 (coenzyme binding)
GO:0051721 (protein phosphatase 2A binding)
GO:0070402 (NADPH binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0006743 (ubiquinone metabolic process)
GO:0007568 (aging)
GO:0007584 (response to nutrient)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0008299 (isoprenoid biosynthetic process)
GO:0008542 (visual learning)
GO:0010142 (farnesyl diphosphate biosynthetic process, mevalonate pathway)
GO:0010664 (negative regulation of striated muscle cell apoptotic process)
GO:0010666 (positive regulation of cardiac muscle cell apoptotic process)
GO:0015936 (coenzyme A metabolic process)
GO:0016126 (sterol biosynthetic process)
GO:0032874 (positive regulation of stress-activated MAPK cascade)
GO:0043066 (negative regulation of apoptotic process)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0045445 (myoblast differentiation)
GO:0045471 (response to ethanol)
GO:0048643 (positive regulation of skeletal muscle tissue development)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051262 (protein tetramerization)
GO:0055114 (oxidation-reduction process)
GO:0061045 (negative regulation of wound healing)
GO:0061179 (negative regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0097756 (negative regulation of blood vessel diameter)

Target Cross References - Protein

canSAR P51639
Guide to Pharmacology 639
Reactome R-RNO-191273 (Cholesterol biosynthesis.)
UniProt P51639 Q64601 Q6P2A6

Target Cross References - Domain

InterPro IPR000731 (SSD.)
IPR002202 (HMG_CoA_Rdtase.)
IPR004554 (HMG_CoA_Rdtase_eu_arc.)
IPR004816 (HMG_CoA_Rdtase_metazoan.)
IPR009023 (HMG_CoA_Rdtase_NAD(P)-bd_sf.)
IPR009029 (HMG_CoA_Rdtase_sub-bd_dom_sf.)
IPR023074 (HMG_CoA_Rdtase_cat_sf.)
IPR023076 (HMG_CoA_Rdtase_CS.)
IPR023282 (HMG_CoA_Rdtase_N.)
Pfam PF00368 (HMG-CoA_red)
PF12349 (Sterol-sensing)