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Target Report Card

Target Name and Classification

Target ID CHEMBL3234
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase HCK
Synonyms HCK | Hematopoietic cell kinase | Hemopoietic cell kinase | Tyrosine-protein kinase HCK | p59-HCK/p60-HCK | p59Hck | p61Hck
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase HCK SINGLE PROTEIN P08631

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363074 SRC PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL288441 BOSUTINIB Tyrosine-protein kinase HCK inhibitor 4 Expert

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101336
Ensembl ENSG00000101336
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005884 (actin filament)
GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0030133 (transport vesicle)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001784 (phosphotyrosine binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0002376 (immune system process)
GO:0002522 (leukocyte migration involved in immune response)
GO:0002758 (innate immune response-activating signal transduction)
GO:0006468 (protein phosphorylation)
GO:0006887 (exocytosis)
GO:0006909 (phagocytosis)
GO:0006954 (inflammatory response)
GO:0007155 (cell adhesion)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007498 (mesoderm development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030154 (cell differentiation)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0043066 (negative regulation of apoptotic process)
GO:0043299 (leukocyte degranulation)
GO:0045087 (innate immune response)
GO:0045728 (respiratory burst after phagocytosis)
GO:0046777 (protein autophosphorylation)
GO:0050690 (regulation of defense response to virus by virus)
GO:0050727 (regulation of inflammatory response)
GO:0050764 (regulation of phagocytosis)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0071801 (regulation of podosome assembly)
GO:2000251 (positive regulation of actin cytoskeleton reorganization)
Wikipedia HCK

Target Cross References - Protein

canSAR P08631
Human Protein Atlas ENSG00000101336
IntAct P08631
Guide to Pharmacology 2032
Open Targets ENSG00000101336
PharmGKB PA29216
Pharos P08631 (Tclin)
Reactome R-HSA-164944 (Nef and signal transduction.)
R-HSA-2029481 (FCGR activation.)
R-HSA-912631 (Regulation of signaling by CBL.)
UniProt A8K1I1 B4DQB6 E1P5M2 P08631 Q29RX1 Q2VPE2 Q504R5 Q5T7K1 Q5T7K2 Q96CC0 Q9H5Y5 Q9NUA4 Q9UMJ5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR035851 (HCK_SH2.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4LUD 4LUE More...
CREDO 1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4LUD 4LUE More...
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