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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3230
Preferred Name Sphingosine 1-phosphate receptor Edg-6
Synonyms EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | Sphingosine 1-phosphate receptor 4 | Sphingosine 1-phosphate receptor Edg-6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > edg receptor

Target Components

Component Description Relationship Accession
Sphingosine 1-phosphate receptor 4 SINGLE PROTEIN O95977

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363041 Sphingosine 1-phosphate receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125910
Ensembl ENSG00000125910
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0008289 (lipid binding)
GO:0038036 (sphingosine-1-phosphate receptor activity)
GO Biological Process GO:0003376 (sphingosine-1-phosphate signaling pathway)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
Wikipedia S1PR4

Target Cross References - Protein

canSAR O95977
Human Protein Atlas ENSG00000125910
IntAct O95977
Guide to Pharmacology 278
Open Targets ENSG00000125910
PharmGKB PA162402371
Pharos O95977 (Tclin)
Reactome R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-419408 (Lysosphingolipid and LPA receptors.)
UniProt D6W612 O95977

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR004061 (S1P_rcpt.)
IPR004064 (EDG6_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)