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Target Report Card

Target Name and Classification

Target ID CHEMBL322
Preferred Name Serotonin 2a (5-HT2a) receptor
Synonyms 5-HT-2 | 5-HT-2A | 5-hydroxytryptamine receptor 2A | Htr2 | Htr2a | Serotonin receptor 2A
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 2A SINGLE PROTEIN P14842

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094123 Serotonin (5-HT) receptor PROTEIN FAMILY
CHEMBL2111383 Serotonin receptor 2a and 2c (5HT2A and 5HT2C) SELECTIVITY GROUP
CHEMBL2111398 Serotonin receptor 2a and 2b (5HT2A and 5HT2B) SELECTIVITY GROUP
CHEMBL2097175 Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor SELECTIVITY GROUP
CHEMBL2093870 Serotonin 2 (5-HT2) receptor PROTEIN FAMILY
CHEMBL2111406 Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031410 (cytoplasmic vesicle)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0043198 (dendritic shaft)
GO:0070852 (cell body fiber)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0030594 (neurotransmitter receptor activity)
GO:0044877 (macromolecular complex binding)
GO:0051378 (serotonin binding)
GO:0071886 (1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007208 (phospholipase C-activating serotonin receptor signaling pathway)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007568 (aging)
GO:0007610 (behavior)
GO:0007613 (memory)
GO:0008219 (cell death)
GO:0008284 (positive regulation of cell proliferation)
GO:0010513 (positive regulation of phosphatidylinositol biosynthetic process)
GO:0014059 (regulation of dopamine secretion)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0014824 (artery smooth muscle contraction)
GO:0014832 (urinary bladder smooth muscle contraction)
GO:0019233 (sensory perception of pain)
GO:0030431 (sleep)
GO:0033674 (positive regulation of kinase activity)
GO:0042493 (response to drug)
GO:0043267 (negative regulation of potassium ion transport)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0044380 (protein localization to cytoskeleton)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045821 (positive regulation of glycolytic process)
GO:0045907 (positive regulation of vasoconstriction)
GO:0048148 (behavioral response to cocaine)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050965 (detection of temperature stimulus involved in sensory perception of pain)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)

Target Cross References - Protein

canSAR P14842
IntAct P14842
Guide to Pharmacology 6
MICAD NBK23366 (5-HT2A serotonin receptors)
NBK53688 (5-HT2A serotonin receptor)
Reactome R-RNO-390666 (Serotonin receptors.)
R-RNO-416476 (G alpha (q) signalling events.)
UniProt P14842

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000455 (5HT2A_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure