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Target Report Card

Target Name and Classification

Target ID CHEMBL3201
Preferred Name Aryl hydrocarbon receptor
Synonyms AHR | Ah receptor | AhR | Aryl hydrocarbon receptor | BHLHE76 | Class E basic helix-loop-helix protein 76 | bHLHe76
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Aryl hydrocarbon receptor SINGLE PROTEIN P35869

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106546
Ensembl ENSG00000106546
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0032991 (macromolecular complex)
GO:0034751 (aryl hydrocarbon receptor complex)
GO:0034752 (cytosolic aryl hydrocarbon receptor complex)
GO:0034753 (nuclear aryl hydrocarbon receptor complex)
GO Molecular Function GO:0001094 (TFIID-class transcription factor binding)
GO:0001223 (transcription coactivator binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004874 (aryl hydrocarbon receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0017025 (TBP-class protein binding)
GO:0035326 (enhancer binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046982 (protein heterodimerization activity)
GO:0046983 (protein dimerization activity)
GO:0051879 (Hsp90 protein binding)
GO:0070888 (E-box binding)
GO Biological Process GO:0001568 (blood vessel development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006805 (xenobiotic metabolic process)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0009410 (response to xenobiotic stimulus)
GO:0009636 (response to toxic substance)
GO:0010468 (regulation of gene expression)
GO:0019933 (cAMP-mediated signaling)
GO:0030522 (intracellular receptor signaling pathway)
GO:0030888 (regulation of B cell proliferation)
GO:0032922 (circadian regulation of gene expression)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0071320 (cellular response to cAMP)
GO:1904322 (cellular response to forskolin)
GO:1904613 (cellular response to 2,3,7,8-tetrachlorodibenzodioxine)
Wikipedia Aryl_hydrocarbon_receptor

Target Cross References - Protein

canSAR P35869
Human Protein Atlas ENSG00000106546
IntAct P35869
Guide to Pharmacology 2951
Open Targets ENSG00000106546
PharmGKB PA24641
Reactome R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-211945 (Phase I - Functionalization of compounds.)
R-HSA-211976 (Endogenous sterols.)
R-HSA-211981 (Xenobiotics.)
R-HSA-8937144 (Aryl hydrocarbon receptor signalling.)
UniProt A4D130 P35869 Q13728 Q13803 Q13804

Target Cross References - Domain

InterPro IPR000014 (PAS.)
IPR001610 (PAC.)
IPR011598 (bHLH_dom.)
IPR013655 (PAS_fold_3.)
IPR013767 (PAS_fold.)
IPR033348 (AHR.)
IPR035965 (PAS-like_dom_sf.)
IPR036638 (HLH_DNA-bd_sf.)
Pfam PF00010 (HLH)
PF00989 (PAS)
PF08447 (PAS_3)

Target Cross References - Structure