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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3192
Preferred Name Histone deacetylase 8
Synonyms HD8 | HDAC8 | HDACL1 | Histone deacetylase 8
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class i

Target Components

Component Description Relationship Accession
Histone deacetylase 8 SINGLE PROTEIN Q9BY41

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038483 Histone deacetylase 1/3/5/8 PROTEIN FAMILY
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY
CHEMBL3885589 Histone deacetylase 1/8 PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL272980 MOCETINOSTAT Histone deacetylase 8 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000147099
Ensembl ENSG00000147099
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0000228 (nuclear chromosome)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0019213 (deacetylase activity)
GO:0030544 (Hsp70 protein binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0046872 (metal ion binding)
GO:0051879 (Hsp90 protein binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006325 (chromatin organization)
GO:0006333 (chromatin assembly or disassembly)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007062 (sister chromatid cohesion)
GO:0010629 (negative regulation of gene expression)
GO:0016575 (histone deacetylation)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0031647 (regulation of protein stability)
GO:0032204 (regulation of telomere maintenance)
GO:0035984 (cellular response to trichostatin A)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0070932 (histone H3 deacetylation)
GO:0071922 (regulation of cohesin loading)
GO:1904322 (cellular response to forskolin)
GO:2000616 (negative regulation of histone H3-K9 acetylation)
Wikipedia HDAC8

Target Cross References - Protein

canSAR Q9BY41
Human Protein Atlas ENSG00000147099
IntAct Q9BY41
Guide to Pharmacology 2619
Open Targets ENSG00000147099
PharmGKB PA37766
Reactome R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3214815 (HDACs deacetylate histones.)
UniProt A6ND12 A6ND61 A6NET3 A6NJR3 A8MQ62 B4DKN0 B4DV22 Q86VC8 Q9BY41 Q9NP76 Q9NYH4

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR003084 (His_deacetylse_1.)
IPR023696 (Ureohydrolase_dom_sf.)
IPR023801 (His_deacetylse_dom.)
IPR037138 (His_deacetylse_dom_sf.)
Pfam PF00850 (Hist_deacetyl)

Target Cross References - Structure

PDBe 1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH 4QA0 4QA1 4QA2 More...
CREDO 1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH 4QA0 4QA1 4QA2 More...