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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL319
Preferred Name Alpha-1a adrenergic receptor
Synonyms Adra1a | Adra1c | Alpha-1A adrenergic receptor | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-1A adrenergic receptor SINGLE PROTEIN P43140

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907610 Adrenergic receptor alpha-1 PROTEIN FAMILY
CHEMBL2097171 Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 SELECTIVITY GROUP
CHEMBL2094111 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2111447 Alpha adrenergic receptor 1A and 1D SELECTIVITY GROUP
CHEMBL2111476 Alpha adrenergic receptor 1A and 1B SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005575 (cellular_component)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030018 (Z disc)
GO:0030315 (T-tubule)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004937 (alpha1-adrenergic receptor activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001985 (negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)
GO:0001994 (norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)
GO:0001996 (positive regulation of heart rate by epinephrine-norepinephrine)
GO:0001997 (positive regulation of the force of heart contraction by epinephrine-norepinephrine)
GO:0003084 (positive regulation of systemic arterial blood pressure)
GO:0006937 (regulation of muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007512 (adult heart development)
GO:0007568 (aging)
GO:0009725 (response to hormone)
GO:0010460 (positive regulation of heart rate)
GO:0010507 (negative regulation of autophagy)
GO:0010613 (positive regulation of cardiac muscle hypertrophy)
GO:0019229 (regulation of vasoconstriction)
GO:0032230 (positive regulation of synaptic transmission, GABAergic)
GO:0035024 (negative regulation of Rho protein signal transduction)
GO:0035265 (organ growth)
GO:0042493 (response to drug)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045760 (positive regulation of action potential)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0060073 (micturition)
GO:0060402 (calcium ion transport into cytosol)
GO:0060452 (positive regulation of cardiac muscle contraction)
GO:0061049 (cell growth involved in cardiac muscle cell development)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0090037 (positive regulation of protein kinase C signaling)
GO:0097195 (pilomotor reflex)
GO:1903997 (positive regulation of non-membrane spanning protein tyrosine kinase activity)

Target Cross References - Protein

canSAR P43140
Guide to Pharmacology 22
Reactome R-RNO-390696 (Adrenoceptors.)
R-RNO-416476 (G alpha (q) signalling events.)
R-RNO-416482 (G alpha (12/13) signalling events.)
UniProt P43140

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001004 (ADRA1A_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)