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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3180
Target Type SINGLE PROTEIN
Preferred Name Carboxylesterase 2
Synonyms CE-2 | CES2 | Carboxylesterase 2 | Cocaine esterase | ICE | Methylumbelliferyl-acetate deacetylase 2 | hCE-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Cocaine esterase SINGLE PROTEIN O00748

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172831
Ensembl ENSG00000172831
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO Molecular Function GO:0016787 (hydrolase activity)
GO:0047374 (methylumbelliferyl-acetate deacetylase activity)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0006693 (prostaglandin metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0009056 (catabolic process)
Wikipedia Carboxylesterase_2

Target Cross References - Protein

canSAR O00748
Human Protein Atlas ENSG00000172831
IntAct O00748
Open Targets ENSG00000172831
PharmGKB PA377
Reactome R-HSA-211945 (Phase I - Functionalization of compounds.)
UniProt A8K367 O00748 Q16859 Q5MAB8 Q7Z366 Q8IUP4 Q8TCP8

Target Cross References - Domain

InterPro IPR002018 (CarbesteraseB.)
IPR019819 (Carboxylesterase_B_CS.)
IPR019826 (Carboxylesterase_B_AS.)
IPR029058 (AB_hydrolase.)
Pfam PF00135 (COesterase)
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