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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3155
Preferred Name Serotonin 7 (5-HT7) receptor
Synonyms 5-HT-7 | 5-HT-X | 5-HT7 | 5-hydroxytryptamine receptor 7 | HTR7 | Serotonin receptor 7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 7 SINGLE PROTEIN P34969

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096904 Serotonin (5-HT) receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545220 LY2590443 Serotonin 7 (5-HT7) receptor antagonist 2 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000148680
Ensembl ENSG00000148680
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0030594 (neurotransmitter receptor activity)
GO:0051378 (serotonin binding)
GO Biological Process GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007198 (adenylate cyclase-inhibiting serotonin receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007623 (circadian rhythm)
GO:0008015 (blood circulation)
GO:0042310 (vasoconstriction)
Wikipedia 5-HT7_receptor

Target Cross References - Protein

canSAR P34969
Human Protein Atlas ENSG00000148680
IntAct P34969
Guide to Pharmacology 12
Open Targets ENSG00000148680
PharmGKB PA29561
Pharos P34969 (Tclin)
Reactome R-HSA-390666 (Serotonin receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt B5BUP6 P34969 P78336 P78372 P78516 Q5VX01 Q5VX02 Q5VX03

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001069 (5HT_7_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)