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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3150
Target Type SINGLE PROTEIN
Preferred Name Vitamin D receptor
Synonyms 1,25-dihydroxyvitamin D3 receptor | Nr1i1 | Nuclear receptor subfamily 1 group I member 1 | VDR | Vdr | Vitamin D3 receptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group i > nuclear hormone receptor subfamily 1 group i member 1

Target Components

Component Description Relationship Accession
Vitamin D3 receptor SINGLE PROTEIN P13053

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000791 (euchromatin)
GO:0000792 (heterochromatin)
GO:0001651 (dense fibrillar component)
GO:0005634 (nucleus)
GO:0005720 (nuclear heterochromatin)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005901 (caveola)
GO:0016363 (nuclear matrix)
GO:0030315 (T-tubule)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0005499 (vitamin D binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0008434 (calcitriol receptor activity)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:1902098 (calcitriol binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0007507 (heart development)
GO:0007568 (aging)
GO:0032355 (response to estradiol)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0051592 (response to calcium ion)
GO:0051924 (regulation of calcium ion transport)
GO:0070561 (vitamin D receptor signaling pathway)
GO:0071305 (cellular response to vitamin D)
GO:0097190 (apoptotic signaling pathway)
GO:1904646 (cellular response to beta-amyloid)

Target Cross References - Protein

canSAR P13053
Guide to Pharmacology 605
UniProt P13053

Target Cross References - Domain

InterPro IPR000324 (VitD_rcpt.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 2ZL9 2ZLA 2ZLC 2ZMH 2ZMI 2ZMJ 2ZXM 2ZXN 3A2H 3AFR 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW More...
CREDO 1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 2ZL9 2ZLA 2ZLC 2ZMH 2ZMI 2ZMJ 2ZXM 2ZXN 3A2H 3AFR 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW More...
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