ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3130
Target Type SINGLE PROTEIN
Preferred Name PI3-kinase p110-delta subunit
Synonyms PI3-kinase subunit delta | PI3K-delta | PI3Kdelta | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | PtdIns-3-kinase subunit delta | PtdIns-3-kinase subunit p110-delta | p110delta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform SINGLE PROTEIN O00329

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559703 PI3-kinase class I PROTEIN COMPLEX GROUP
CHEMBL2111432 PI3-kinase p110-delta/p85-alpha PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2216870 IDELALISIB PI3-kinase p110-delta subunit inhibitor 4 FDA
CHEMBL3039502 DUVELISIB PI3-kinase p110-delta subunit inhibitor 3 PubMed
CHEMBL3545267 TGR-1202 PI3-kinase p110-delta subunit inhibitor 3 Other
CHEMBL230011 TG100-115 PI3-kinase p110-delta subunit inhibitor 2 PubMed
CHEMBL3545048 AMG-319 PI3-kinase p110-delta subunit inhibitor 2 Other PubMed
CHEMBL3545052 CUDC-907 PI3-kinase p110-delta subunit inhibitor 2 Other PubMed
CHEMBL3545054 INCB-40093 PI3-kinase p110-delta subunit inhibitor 2 Other
CHEMBL3545250 GSK-2269557 PI3-kinase p110-delta subunit inhibitor 2 PubMed
CHEMBL3545397 Acalisib PI3-kinase p110-delta subunit inhibitor 2 PubMed
CHEMBL3545112 ME-401 PI3-kinase p110-delta subunit inhibitor 1 Other
CHEMBL3545141 RP-6530 PI3-kinase p110-delta subunit inhibitor 1 DOI Other
CHEMBL3545205 INCB-040093 PI3-kinase p110-delta subunit inhibitor 1 Other Other
CHEMBL3545247 CAL-263 PI3-kinase p110-delta subunit inhibitor 1 PubMed PubMed
CHEMBL3545424 AZD-8186 PI3-kinase p110-delta subunit inhibitor 1 PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171608
Ensembl ENSG00000171608
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005942 (phosphatidylinositol 3-kinase complex)
GO:0042629 (mast cell granule)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0016740 (transferase activity)
GO:0035004 (phosphatidylinositol 3-kinase activity)
GO:0035005 (1-phosphatidylinositol-4-phosphate 3-kinase activity)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO Biological Process GO:0001779 (natural killer cell differentiation)
GO:0001816 (cytokine production)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002551 (mast cell chemotaxis)
GO:0002679 (respiratory burst involved in defense response)
GO:0006468 (protein phosphorylation)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0010628 (positive regulation of gene expression)
GO:0010818 (T cell chemotaxis)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0030101 (natural killer cell activation)
GO:0030154 (cell differentiation)
GO:0030217 (T cell differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0030593 (neutrophil chemotaxis)
GO:0035747 (natural killer cell chemotaxis)
GO:0035754 (B cell chemotaxis)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0042110 (T cell activation)
GO:0042113 (B cell activation)
GO:0043303 (mast cell degranulation)
GO:0045087 (innate immune response)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0050852 (T cell receptor signaling pathway)
GO:0050853 (B cell receptor signaling pathway)
GO:0060374 (mast cell differentiation)
GO:0072672 (neutrophil extravasation)
Wikipedia P110%CE%B4

Target Cross References - Protein

canSAR O00329
Human Protein Atlas ENSG00000171608
IntAct O00329
Guide to Pharmacology 2155
Open Targets ENSG00000171608
PharmGKB PA33310
Pharos O00329 (Tclin)
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1660499 (Synthesis of PIPs at the plasma membrane.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-512988 (Interleukin-3, 5 and GM-CSF signaling.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-8853659 (RET signaling.)
R-HSA-912526 (Interleukin receptor SHC signaling.)
R-HSA-912631 (Regulation of signaling by CBL.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt A6NCG0 G1FFP1 O00329 O15445 Q5SR49

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000341 (PI3K_Ras-bd_dom.)
IPR000403 (PI3/4_kinase_cat_dom.)
IPR001263 (PInositide-3_kin_accessory_dom.)
IPR002420 (PI3K_C2_dom.)
IPR003113 (PI3K_adapt-bd_dom.)
IPR011009 (Kinase-like_dom.)
IPR015433 (PI_Kinase.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
IPR029071 (Ubiquitin-rel_dom.)
Pfam PF00454 (PI3_PI4_kinase)
PF00613 (PI3Ka)
PF00792 (PI3K_C2)
PF00794 (PI3K_rbd)
PF02192 (PI3K_p85B)

Target Cross References - Structure

PDBe 5DXU 5M6U 5T8F
CREDO 5DXU 5M6U 5T8F
spacer
spacer