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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3091268
Target Type SINGLE PROTEIN
Preferred Name Nuclear receptor ROR-beta
Synonyms NR1F2 | Nuclear receptor ROR-beta | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RZRB | Retinoid-related orphan receptor-beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group f

Target Components

Component Description Relationship Accession
Nuclear receptor ROR-beta SINGLE PROTEIN Q92753

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198963
Ensembl ENSG00000198963
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007275 (multicellular organism development)
GO:0007601 (visual perception)
GO:0030522 (intracellular receptor signaling pathway)
GO:0035881 (amacrine cell differentiation)
GO:0042462 (eye photoreceptor cell development)
GO:0042752 (regulation of circadian rhythm)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046548 (retinal rod cell development)
GO:0046549 (retinal cone cell development)
GO:0048511 (rhythmic process)
GO:0050896 (response to stimulus)
GO:0060041 (retina development in camera-type eye)
GO:0071300 (cellular response to retinoic acid)

Target Cross References - Protein

Human Protein Atlas ENSG00000198963
IntAct Q92753
Guide to Pharmacology 599
Open Targets ENSG00000198963
Pharos Q92753 (Tchem)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt Q8WX73 Q92753

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003079 (ROR_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
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