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Target Report Card

Target Name and Classification

Target ID CHEMBL308
Target Type SINGLE PROTEIN
Preferred Name Cyclin-dependent kinase 1
Synonyms CDC2 | CDC28A | CDK1 | CDK1 | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 | P34CDC2 | p34 protein kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdc2 subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 1 SINGLE PROTEIN P06493

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY
CHEMBL2094127 Cyclin-dependent kinase 1/cyclin B PROTEIN COMPLEX
CHEMBL3038467 CDK1/Cyclin A PROTEIN COMPLEX
CHEMBL3038468 CDK1/Cyclin E PROTEIN COMPLEX
CHEMBL1907602 Cyclin-dependent kinase 1/cyclin B1 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL428690 ALVOCIDIB Cyclin-dependent kinase 1 inhibitor 3 PubMed PubMed
CHEMBL2103840 DINACICLIB Cyclin-dependent kinase 1 inhibitor 3 PubMed
CHEMBL14762 SELICICLIB Cyclin-dependent kinase 1 inhibitor 2 PubMed PubMed PubMed
CHEMBL384304 RG-547 Cyclin-dependent kinase 1 inhibitor 2
CHEMBL564829 MILCICLIB Cyclin-dependent kinase 1 inhibitor 2 PubMed PubMed
CHEMBL3545283 Riviciclib Cyclin-dependent kinase 1 inhibitor 2 PubMed PubMed
CHEMBL1944698 TG-02 Cyclin-dependent kinase 1 inhibitor 1 PubMed
CHEMBL3545083 RGB-286638 Cyclin-dependent kinase 1 inhibitor 1 PubMed
CHEMBL3545420 AG-24322 Cyclin-dependent kinase 1 inhibitor 1 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170312
Ensembl ENSG00000170312
GO Cellular Component GO:0000784 (nuclear chromosome, telomeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005876 (spindle microtubule)
GO:0016020 (membrane)
GO:0030496 (midbody)
GO:0070062 (extracellular exosome)
GO:0072686 (mitotic spindle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008353 (RNA polymerase II carboxy-terminal domain kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030332 (cyclin binding)
GO:0030544 (Hsp70 protein binding)
GO:0035173 (histone kinase activity)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000083 (regulation of transcription involved in G1/S transition of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000187 (activation of MAPK activity)
GO:0000226 (microtubule cytoskeleton organization)
GO:0000278 (mitotic cell cycle)
GO:0006260 (DNA replication)
GO:0006281 (DNA repair)
GO:0006461 (protein complex assembly)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007049 (cell cycle)
GO:0007067 (mitotic nuclear division)
GO:0007077 (mitotic nuclear envelope disassembly)
GO:0007095 (mitotic G2 DNA damage checkpoint)
GO:0007098 (centrosome cycle)
GO:0007344 (pronuclear fusion)
GO:0007569 (cell aging)
GO:0009636 (response to toxic substance)
GO:0010243 (response to organonitrogen compound)
GO:0010628 (positive regulation of gene expression)
GO:0014038 (regulation of Schwann cell differentiation)
GO:0014070 (response to organic cyclic compound)
GO:0014075 (response to amine)
GO:0014823 (response to activity)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0016572 (histone phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0030261 (chromosome condensation)
GO:0030855 (epithelial cell differentiation)
GO:0031100 (organ regeneration)
GO:0031145 (anaphase-promoting complex-dependent catabolic process)
GO:0033160 (positive regulation of protein import into nucleus, translocation)
GO:0034501 (protein localization to kinetochore)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0042787 (protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0045471 (response to ethanol)
GO:0045740 (positive regulation of DNA replication)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0045995 (regulation of embryonic development)
GO:0046686 (response to cadmium ion)
GO:0046688 (response to copper ion)
GO:0048678 (response to axon injury)
GO:0051301 (cell division)
GO:0051436 (negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle)
GO:0051437 (positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition)
GO:0051439 (regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle)
GO:0055015 (ventricular cardiac muscle cell development)
GO:0060045 (positive regulation of cardiac muscle cell proliferation)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0090166 (Golgi disassembly)
GO:1900182 (positive regulation of protein localization to nucleus)
Wikipedia Cyclin-dependent_kinase_1

Target Cross References - Protein

Human Protein Atlas ENSG00000170312
IntAct P06493
Guide to Pharmacology 1961
Open Targets ENSG00000170312
PharmGKB PA99
Pharos P06493 (Tchem)
Reactome R-HSA-110056 (MAPK3 (ERK1) activation.)
R-HSA-113507 (E2F-enabled inhibition of pre-replication complex formation.)
R-HSA-113510 (E2F mediated regulation of DNA replication.)
R-HSA-1538133 (G0 and Early G1.)
R-HSA-157881 (Cyclin B2 mediated events.)
R-HSA-162658 (Golgi Cisternae Pericentriolar Stack Reorganization.)
R-HSA-170145 (Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes.)
R-HSA-174048 (APC/C:Cdc20 mediated degradation of Cyclin B.)
R-HSA-174184 (Cdc20:Phospho-APC/C mediated degradation of Cyclin A.)
R-HSA-176408 (Regulation of APC/C activators between G1/S and early anaphase.)
R-HSA-176412 (Phosphorylation of the APC/C.)
R-HSA-176417 (Phosphorylation of Emi1.)
R-HSA-2299718 (Condensation of Prophase Chromosomes.)
R-HSA-2465910 (MASTL Facilitates Mitotic Progression.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-2514853 (Condensation of Prometaphase Chromosomes.)
R-HSA-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-HSA-2980767 (Activation of NIMA Kinases NEK9, NEK6, NEK7.)
R-HSA-3301854 (Nuclear Pore Complex (NPC) Disassembly.)
R-HSA-380259 (Loss of Nlp from mitotic centrosomes.)
R-HSA-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-HSA-380284 (Loss of proteins required for interphase microtubule organization from the centrosome.)
R-HSA-380320 (Recruitment of NuMA to mitotic centrosomes.)
R-HSA-4419969 (Depolymerisation of the Nuclear Lamina.)
R-HSA-5620912 (Anchoring of the basal body to the plasma membrane.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-6804114 (TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.)
R-HSA-6804757 (Regulation of TP53 Degradation.)
R-HSA-69205 (G1/S-Specific Transcription.)
R-HSA-69273 (Cyclin A/B1 associated events during G2/M transition.)
R-HSA-69478 (G2/M DNA replication checkpoint.)
R-HSA-75035 (Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.)
R-HSA-8852276 (The role of GTSE1 in G2/M progression after G2 checkpoint.)
R-HSA-8854518 (AURKA Activation by TPX2.)
UniProt A8K7C4 C9J497 O60764 P06493

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4Y72 4YC3 4YC6 5HQ0 5LQF
CREDO 4Y72 4YC3 4YC6 5HQ0 5LQF
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