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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3018
Target Type SINGLE PROTEIN
Preferred Name Matriptase
Synonyms MT-SP1 | Matriptase | Membrane-type serine protease 1 | PRSS14 | Prostamin | SNC19 | ST14 | Serine protease 14 | Serine protease TADG-15 | Suppressor of tumorigenicity 14 protein | TADG15 | Tumor-associated differentially-expressed gene 15 protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Suppressor of tumorigenicity 14 protein SINGLE PROTEIN Q9Y5Y6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149418
Ensembl ENSG00000149418
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0019897 (extrinsic component of plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0001843 (neural tube closure)
GO:0006508 (proteolysis)
GO:0030216 (keratinocyte differentiation)
GO:0060672 (epithelial cell morphogenesis involved in placental branching)

Target Cross References - Protein

canSAR Q9Y5Y6
CGD Ichthyosis with hypotrichosis
Human Protein Atlas ENSG00000149418
IntAct Q9Y5Y6
Guide to Pharmacology 2418
Open Targets ENSG00000149418
PharmGKB PA36168
UniProt Q9BS01 Q9H3S0 Q9HB36 Q9HCA3 Q9Y5Y6

Target Cross References - Domain

InterPro IPR000082 (SEA_dom.)
IPR000859 (CUB_dom.)
IPR001254 (Trypsin_dom.)
IPR002172 (LDrepeatLR_classA_rpt.)
IPR009003 (Peptidase_S1_PA.)
IPR017051 (Peptidase_S1A_matripase.)
IPR018114 (TRYPSIN_HIS.)
IPR023415 (LDLR_class-A_CS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00057 (Ldl_recept_a)
PF00089 (Trypsin)
PF00431 (CUB)
PF01390 (SEA)

Target Cross References - Structure

PDBe 1EAW 1EAX 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V
CREDO 1EAW 1EAX 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V
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