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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2993
Target Type SINGLE PROTEIN
Preferred Name Monoamine oxidase B
Synonyms Amine oxidase [flavin-containing] B | MAO-B | Maob | Monoamine oxidase type B
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Amine oxidase [flavin-containing] B SINGLE PROTEIN P19643

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095196 Monoamine oxidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0008131 (primary amine oxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0042803 (protein homodimerization activity)
GO:0050660 (flavin adenine dinucleotide binding)
GO Biological Process GO:0009636 (response to toxic substance)
GO:0010044 (response to aluminum ion)
GO:0010269 (response to selenium ion)
GO:0014063 (negative regulation of serotonin secretion)
GO:0032496 (response to lipopolysaccharide)
GO:0042135 (neurotransmitter catabolic process)
GO:0042493 (response to drug)
GO:0045471 (response to ethanol)
GO:0045964 (positive regulation of dopamine metabolic process)
GO:0048545 (response to steroid hormone)
GO:0051412 (response to corticosterone)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P19643
Guide to Pharmacology 2490
Reactome R-RNO-141333 (Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.)
UniProt P19643 Q5EBB5

Target Cross References - Domain

InterPro IPR001613 (Flavin_amine_oxidase.)
IPR002937 (Amino_oxidase.)
IPR036188 (FAD/NAD-bd_sf.)
Pfam PF01593 (Amino_oxidase)
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