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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2954
Preferred Name Cathepsin S
Synonyms CTSS | Cathepsin S
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c1a family

Target Components

Component Description Relationship Accession
Cathepsin S SINGLE PROTEIN P25774

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111368 Cathepsin (S and K) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163131
Ensembl ENSG00000163131
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005764 (lysosome)
GO:0036021 (endolysosome lumen)
GO:0043202 (lysosomal lumen)
GO:0043231 (intracellular membrane-bounded organelle)
GO:1904724 (tertiary granule lumen)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0001968 (fibronectin binding)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005518 (collagen binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0043236 (laminin binding)
GO:0043394 (proteoglycan binding)
GO Biological Process GO:0002224 (toll-like receptor signaling pathway)
GO:0002250 (adaptive immune response)
GO:0006508 (proteolysis)
GO:0006955 (immune response)
GO:0010447 (response to acidic pH)
GO:0016485 (protein processing)
GO:0019882 (antigen processing and presentation)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0034769 (basement membrane disassembly)
GO:0043312 (neutrophil degranulation)
GO:0048002 (antigen processing and presentation of peptide antigen)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0097067 (cellular response to thyroid hormone stimulus)
GO:2001259 (positive regulation of cation channel activity)
Wikipedia Cathepsin_S

Target Cross References - Protein

canSAR P25774
Human Protein Atlas ENSG00000163131
IntAct P25774
Guide to Pharmacology 2353
Open Targets ENSG00000163131
PharmGKB PA27041
Reactome R-HSA-1236977 (Endosomal/Vacuolar pathway.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1679131 (Trafficking and processing of endosomal TLR.)
R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B4DWC9 D3DV05 P25774 Q5T5I0 Q6FHS5 Q9BUG3

Target Cross References - Domain

InterPro IPR000169 (Pept_cys_AS.)
IPR000668 (Peptidase_C1A_C.)
IPR013128 (Peptidase_C1A.)
IPR013201 (Prot_inhib_I29.)
IPR025660 (Pept_his_AS.)
IPR025661 (Pept_asp_AS.)
Pfam PF00112 (Peptidase_C1)
PF08246 (Inhibitor_I29)

Target Cross References - Structure

PDBe 1GLO 1MS6 1NPZ 1NQC 2C0Y 2F1G 2FQ9 2FRA 2FRQ 2FT2 2FUD 2FYE 2G6D 2G7Y 2H7J 2HH5 2HHN 2HXZ 2OP3 2R9M 2R9N 2R9O 3IEJ 3N3G More...
CREDO 1GLO 1MS6 1NPZ 1NQC 2C0Y 2F1G 2FQ9 2FRA 2FRQ 2FT2 2FUD 2FYE 2G6D 2G7Y 2H7J 2HH5 2HHN 2HXZ 2OP3 2R9M 2R9N 2R9O 3IEJ 3N3G More...