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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2949
Target Type SINGLE PROTEIN
Preferred Name Cyclooxygenase-1
Synonyms COX-1 | COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1
Organism Ovis aries
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 1 SINGLE PROTEIN P05979

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111358 Prostaglandin G/H synthase (cyclooxygenase) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0008217 (regulation of blood pressure)
GO:0019371 (cyclooxygenase pathway)
GO:0055114 (oxidation-reduction process)
GO:0098869 (cellular oxidant detoxification)

Target Cross References - Protein

canSAR P05979
UniProt P05979

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029580 (COX-1.)
Pfam PF00008 (EGF)
PF03098 (An_peroxidase)

Target Cross References - Structure

PDBe 1CQE 1DIY 1EBV 1EQG 1EQH 1FE2 1HT5 1HT8 1IGX 1IGZ 1PGE 1PGF 1PGG 1PRH 1PTH 1Q4G 1U67 2AYL 2OYE 2OYU 3KK6 3N8V 3N8W 3N8X More...
CREDO 1CQE 1DIY 1EBV 1EQG 1EQH 1FE2 1HT5 1HT8 1IGX 1IGZ 1PGE 1PGF 1PGG 1PRH 1PTH 1Q4G 1U67 2AYL 2OYE 2OYU 3KK6 3N8V 3N8W 3N8X More...
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